ArticleAngewandte Chemie (International ed. in English)2019
Palladium-Catalyzed Dearomative syn-1,4-Carboamination with Grignard Reagents.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- Photoinduced Hydrogenative Dearomatization With Homocoupling of Quinolines to Construct Octahydro-4,4'-biquinolines.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
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- Site-Selective Benzylic Dehydrogenation of Alkylindoles.JACS Au · 2025Article
- Three-Way Chemodivergent Derivatization of Non-Activated 2-Arylphenyl Benzyl Ethers.The Journal of organic chemistry · 2025Article
- Reimagining Dearomatization: Arenophile-Mediated Single-Atom Insertions and π-Extensions.Accounts of chemical research · 2025Article
- Intermolecular Asymmetric Arylative Dearomatization of 1-Naphthols.Journal of the American Chemical Society · 2024Article
- Palladium-catalyzed dearomative 1,4-hydroamination.Tetrahedron · 2024Article
- Copper-Catalyzed Dearomative 1,2-Hydroamination.Angewandte Chemie (International ed. in English) · 2024Article
- Copper-Catalyzed DearomativeACS catalysis · 2024Article
- Photochemical dearomative skeletal modifications of heteroaromatics.Chemical Society reviews · 2024Review
- Catalytic Asymmetric Construction of α,α-Diaryl Aldehydes via Oxo-Hydroarylation of Terminal Alkynes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Switchable chemoselective aryne reactions between nucleophiles and pericyclic reaction partners using either 3-methoxybenzyne or 3-silylbenzyne.Nature communications · 2024Article
- Recent Strategies in the Nucleophilic Dearomatization of Pyridines, Quinolines, and Isoquinolines.Chemical reviews · 2024Review
- Metal-free photosensitized radical relay 1,4-carboimination across two distinct olefins.Chemical science · 2023Article
- π-Extended Rubrenes via Dearomative Annulative π-Extension Reaction.Journal of the American Chemical Society · 2023Article
- Dearomative logic in natural product total synthesis.Natural product reports · 2022Review
- Asymmetric dearomative cyclopropanation of naphthalenes to construct polycyclic compounds.Chemical science · 2022Article
- Diversity-oriented synthesis of nanographenes enabled by dearomative annulative π-extension.Nature communications · 2021Article
- Advances in Catalytic Asymmetric Dearomatization.ACS central science · 2021Review
- Catalytic three-component C-C bond forming dearomatization of bromoarenes with malonates and diazo compounds.Chemical science · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
A protocol for palladium-catalyzed dearomative functionalization of simple, nonactivated arenes with Grignard reagents has been established. This one-pot method features a visible-light-mediated [4+2] cycloaddition between an arene and an arenophile, and subsequent palladium-catalyzed allylic substitution of the resulting cycloadduct with a Grignard reagent. A variety of arenes and Grignard reagents can participate in this process, forming carboaminated products with exclusive syn-1,4-selectivity. Moreover, the dearomatized products are amenable to further elaborations, providing functionalized alicyclic motifs and pharmacophores. For example, naphthalene was converted into sertraline, one of the most prescribed antidepressants, in only four operations. Finally, this process could also be conducted in an enantioselective fashion, as demonstrated with the desymmetrization of naphthalene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.