ArticleJournal of occupational health2019
Allergen-specific IgE to recombinant latex allergens in occupational allergy diagnostics.
Article in Journal of occupational health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Latex allergy and medical aspects of the use of latex products.Postepy dermatologii i alergologii · 2026Review
- Protein microarray allergen profiling in bronchoalveolar lavage fluid and serum of horses with asthma.Journal of veterinary internal medicine · 2023Article
- VALIDA project: Validation of allergyAdvances in laboratory medicine · 2020Review
- Allergic contact dermatitis caused by elastic bands from FFP2 mask.Contact dermatitis · 2020Article
- Latex Allergy: Current Status and Future Perspectives.Journal of asthma and allergy · 2020Review
- Allergen-specific IgE to recombinant latex allergens in occupational allergy diagnostics.Journal of occupational health · 2019Article
- Latex allergy guidelines for people with spina bifida.Journal of pediatric rehabilitation medicineReview
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSpecific challenge tests (SICs) are considered reference tests for allergic occupational diseases diagnosis. However, in numerous cases, SICs cannot be carried out in the diagnosis of allergy to latex due to the risk of generalized reactions. The aim of the study was to evaluate the usefulness of sIgE determination to recombinant latex allergens in diagnostics of occupational respiratory allergy. MATERIALS AND
methodsThe study group comprised 44 healthcare workers (HCW) suspected of suffering from occupational respiratory allergy to latex (they underwent a physical examination, skin-prick tests (SPTs) to common and latex allergens, spirometry and SIC) and 17 controls not occupationally exposed to latex, with a positive sIgE against latex. Each serum was tested for allergen-specific IgE to aeroallergens, latex, eight recombinant latex allergens and CCD-markers.
resultsSpecific IgE against Hev b5, 6.01, and 6.02 were significantly more frequently detected in HCWs and their mean serum levels were higher compared with the control group. In 26 HCWs with occupational asthma (OA), sensitization to Hev b5, Hev b6.01, Hev b6.02 was significantly more frequent than in 18 HCWs with work-exacerbated asthma (WEA); they had positive results SPT to latex significantly more frequently in comparison with subjects with WEA.
conclusionsTest for recombinant latex allergens is much more accurate in recognition of latex allergy than test for latex extract, which seems to produce false-positive results in patients with pollen allergy. The measurements of sIgE against recombinant latex allergens Hev b 6.01, 6.02, 5, and 8 are useful in differentiating OA from WEA.
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