Evidence map›Paper›PMID 31090162›Full record

ReviewEuropean journal of cancer care2019

Interventions for cognitive problems in adults with brain cancer: A narrative review.

Pearl J C van Lonkhuizen, Kete M Klaver, Jeffrey S Wefel, Margriet M Sitskoorn, Sanne B Schagen, Karin Gehring

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of cancer care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  19. Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Pearl J C van LonkhuizenDepartment of Cognitive Neuropsychology, Tilburg University, Tilburg, The Netherlands.
Kete M KlaverDivision of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Jeffrey S WefelDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Margriet M SitskoornDepartment of Cognitive Neuropsychology, Tilburg University, Tilburg, The Netherlands.
Sanne B SchagenDivision of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Karin GehringDepartment of Cognitive Neuropsychology, Tilburg University, Tilburg, The Netherlands.
Tilburg University · NLElisabeth-TweeSteden Ziekenhuis · NLThe Netherlands Cancer Institute · NLThe University of Texas MD Anderson Cancer Center · USUniversity of Amsterdam · NL

Funding

ZonMw 842003006ZonMw 842003007ZonMw 842003008ZonMw 842003009
6 · The paper itself

Abstract

introductionMany patients with brain cancer experience cognitive problems. In this narrative review, we comprehensively evaluated empirical studies on various intervention approaches for cognitive problems in these patients.

methodsIntervention studies that reported effects on cognitive functioning (either objectively tested or subjectively reported) in adult patients with primary and/or secondary brain tumours were identified through online searches in PubMed (MEDLINE) and Web of Science up to 13 March 2019.

resultsOf the 364 identified records, 10 pharmacological (including five randomised placebo-controlled trials), 10 cognitive rehabilitation (including five [pilot] RCTs) and two multiple-group exercise studies matched the inclusion criteria. Seventeen of 22 studies had final sample sizes smaller than 40. Several cognitive rehabilitation studies and some pharmacological approaches (donepezil and memantine) showed (at least partial) benefits for cognitive problems in adults with brain cancer. The effects of other pharmacological and exercise interventions were inconclusive and/or preliminary.

conclusionOverall, drawing firm conclusions is complicated due to various methodological shortcomings, including the absence of a (placebo) control group and small sample sizes. Promising effects have been reported for cognitive rehabilitation and some pharmacological approaches. Suggestions for more thorough research with respect to the various approaches are provided.

Indexed as

Cognitive RemediationExerciseBrain NeoplasmsCentral Nervous System StimulantsCholinesterase InhibitorsCognitionCognitive DysfunctionDonepezilDopamine AgentsGinkgo bilobaGinkgo ExtractHumansMemantinePlant ExtractsCentral Nervous System StimulantsCholinesterase InhibitorsDonepezilDopamine AgentsGinkgo biloba extractGinkgo ExtractMemantinePlant Extractsbrain neoplasmscognitionexercise therapyneoplasm metastasispharmacologyrehabilitation

Identifiers

PMID31090162
PMCPMC9285967
OpenAlexW2945559897

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.