Evidence map›Paper›PMID 31090128›Full record

ArticleInternational journal of experimental pathology2019

Myelination key factor krox-20 is downregulated in Schwann cells and murine sciatic nerves infected by Mycobacterium leprae.

Mariane Bertolucci Casalenovo, Patrícia Sammarco Rosa, Daniele Ferreira de Faria Bertoluci, Adriana Sierra Assencio Almeida Barbosa, Dejair Caitano do Nascimento, Vânia Nieto Brito de Souza, Maria Renata Sales Nogueira

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In one paragraph

Article in International journal of experimental pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. What happens when Schwann cells are exposed toIBRO neuroscience reports · 2023
    Review
  3. International journal of molecular sciences · 2023
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mariane Bertolucci CasalenovoSchool of Medicine of Botucatu, São Paulo State University, Botucatu, Brazil.
Patrícia Sammarco RosaLauro de Souza Lima Institute, Secretariat of Health of São Paulo, Bauru, São Paulo, Brazil.
Daniele Ferreira de Faria BertoluciLauro de Souza Lima Institute, Secretariat of Health of São Paulo, Bauru, São Paulo, Brazil.
Adriana Sierra Assencio Almeida BarbosaLauro de Souza Lima Institute, Secretariat of Health of São Paulo, Bauru, São Paulo, Brazil.
Dejair Caitano do NascimentoLauro de Souza Lima Institute, Secretariat of Health of São Paulo, Bauru, São Paulo, Brazil.
Vânia Nieto Brito de SouzaSchool of Medicine of Botucatu, São Paulo State University, Botucatu, Brazil.
Maria Renata Sales NogueiraLauro de Souza Lima Institute, Secretariat of Health of São Paulo, Bauru, São Paulo, Brazil.ORCID 0000-0001-8647-0350
Instituto Lauro de Souza Lima · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schwann cells (SCs) critically maintain the plasticity of the peripheral nervous system. Peripheral nerve injuries and infections stimulate SCs in order to retrieve homeostasis in neural tissues. Previous studies indicate that Mycobacterium leprae (ML) regulates the expression of key factors related to SC identity, suggesting that alterations in cell phenotype may be involved in the pathogenesis of neural damage in leprosy. To better understand whether ML restricts the plasticity of peripheral nerves, the present study sought to determine the expression of Krox-20, Sox-10, c-Jun and p75NTR in SC culture and mice sciatic nerves, both infected by ML Thai-53 strain. Primary SC cultures were stimulated with two different multiplicities of infection (MOI 100:1; MOI 50:1) and assessed after 7 and 14 days. Sciatic nerves of nude mice (NU-Foxn1

Indexed as

Down-RegulationAnimalsCell DifferentiationCells, CulturedDisease Models, AnimalEarly Growth Response Protein 2LeprosyMice, NudeMycobacterium lepraeNeuronal PlasticityReceptors, Nerve Growth FactorSchwann CellsSciatic NerveTissue Culture TechniquesEarly Growth Response Protein 2Egr2 protein, mouseNgfr protein, mouseReceptors, Nerve Growth Factorleprosyschwann cellssciatic nervetranscription factors

Identifiers

PMID31090128
PMCPMC6540694
OpenAlexW2946369790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.