Evidence map›Paper›PMID 31090036›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2020

Outcomes Following Cytoreduction and HIPEC for Pseudomyxoma Peritonei: 10-Year Experience.

Vignesh Narasimhan, Kasmira Wilson, Maneka Britto, Satish Warrier, A Craig Lynch, Michael Michael, Jeanne Tie, Tim Akhurst, Catherine Mitchell, Robert Ramsay and 1 more

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Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
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  9. Low-grade appendiceal mucinous neoplasms: a case series.Journal of surgical case reports · 2025
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  13. Review
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  16. [Incidental finding of appendiceal mucinous neoplasms].Chirurgie (Heidelberg, Germany) · 2023
    Review
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vignesh NarasimhanDepartment of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia. vignesh.narasimhan@petermac.org.ORCID 0000-0002-8964-3082
Kasmira WilsonDepartment of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
Maneka BrittoDepartment of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
Satish WarrierDepartment of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
A Craig LynchDepartment of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
Michael MichaelSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.
Jeanne TieDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
Tim AkhurstSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.
Catherine MitchellSir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.
Robert RamsayDepartment of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
Alexander HeriotDepartment of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPseudomyxoma peritonei (PMP) is a rare clinical presentation, with considerable morbidity and mortality if left untreated. In recent decades, there is growing acceptance for the use of cytoreductive surgery (CRS) with heated intraperitoneal chemotherapy (HIPEC). The aim of this study was to report on our 10-year single-center experience on outcomes following CRS and HIPEC for PMP of appendiceal origin.

methodsA retrospective analysis of a prospectively maintained database of all patients undergoing CRS and HIPEC for PMP of appendiceal origin over a 10-year period at a statewide referral center was conducted.

resultsOne hundred and seventy-five cytoreductive procedures were undertaken in 140 patients. The mean patient age was 57.4 years, with a female preponderance (56%). The median PCI was 16, with 73.1% of cases having a complete cytoreduction. Grade III/IV complications occurred in 36 (20.6%) cases, with no mortalities. The median overall and disease-free survival was 100 months and 40 months, respectively, with a 71% 5-year survival. High-grade histology was the main factor identified as an independent predictor of worse overall survival.

conclusionCRS and HIPEC are safe with acceptable rates of morbidity. It can provide very favorable survival in patients with PMP. High-grade histology is a key prognostic factor associated with a worse overall survival.

Indexed as

Appendiceal NeoplasmsHyperthermia, InducedPercutaneous Coronary InterventionPeritoneal NeoplasmsPseudomyxoma PeritoneiCombined Modality TherapyCytoreduction Surgical ProceduresFemaleHumansMiddle AgedRetrospective StudiesCytoreductive surgeryHyperthermic intraperitoneal chemotherapyPseudomyxoma peritonei

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.