SynthesisJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021
Diagnostic performance of myocardial perfusion imaging with conventional and CZT single-photon emission computed tomography in detecting coronary artery disease: A meta-analysis.
Synthesis in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic value of myocardial perfusion imaging by cadmium zinc telluride single-photon emission computed tomography in patients with suspected or known coronary artery disease: a systematic review and meta-analysis.European journal of nuclear medicine and molecular imaging · 2023Pooled it
- [18F]FDG PET/CT versus [18F]FDG PET/MRI for the diagnosis of colorectal liver metastasis: A systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Blunted heart rate response during dipyridamole stress SPECT is associated with cardiovascular outcomes in an all-comers cohort.BMC cardiovascular disorders · 2026Article
- Deep learning-based obstructive coronary artery disease prediction from myocardial perfusion SPECT.European journal of nuclear medicine and molecular imaging · 2026Article
- Magnetocardiography for Exploratory Risk Stratification in Patients With Three-Vessel Coronary Artery Disease: A Single-Center Prospective Cohort Study.Cardiovascular therapeutics · 2026Article
- Diagnostic Accuracy of Exercise Stress Testing, Stress Echocardiography, Myocardial Scintigraphy, and Cardiac Magnetic Resonance for Obstructive Coronary Artery Disease: Systematic Reviews and Meta-Analyses of 104 Studies Published from 1990 to 2025.Journal of clinical medicine · 2025Review
- Artificial intelligence applied in identifying left ventricular walls in myocardial perfusion scintigraphy images: Pilot study.PloS one · 2025Article
- Assessing the diagnostic value of left ventricular synchrony indices derived from phase analysis by D-SPECT in identifying obstructive coronary artery disease.The international journal of cardiovascular imaging · 2024Article
- The Role of Multimodality Imaging (CT & MR) as a Guide to the Management of Chronic Coronary Syndromes.Journal of clinical medicine · 2024Review
- Improving multi-pinhole CZT myocardial perfusion imaging specificity without changing sensibility by using adapted filter parameters.EJNMMI research · 2024Article
- Exploring coronary microvascular function by quantitative CZT-SPECT: a small step or giant leap for INOCA patients?European journal of nuclear medicine and molecular imaging · 2023Article
- Myocardial perfusion reserve by CZT cameras: A journey inside coronary microvascular circulation. Is it time to leave yet?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Revascularization of non-culprit lesions: A common dilemma.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- The addition of coronary artery calcium to myocardial perfusion: Double or nothing?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prognostic value of combined coronary angiography-derived IMR and myocardial perfusion imaging by CZT SPECT in INOCA.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Editorial: Insights in PET and SPECT: 2023.Frontiers in nuclear medicine · 2023Article
- Regional myocardial perfusion imaging in predicting vessel-related outcome: interplay between the perfusion results and angiographic findings.European journal of nuclear medicine and molecular imaging · 2022Article
- Low-dose dobutamine stress gated blood pool SPECT assessment of left ventricular contractile reserve in ischemic cardiomyopathy: a feasibility study.European journal of nuclear medicine and molecular imaging · 2022Article
- Prone-only SPECT myocardial perfusion imaging: An alternative standard in clinical practice?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Is the CZT technology the future of nuclear cardiology?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe performed a meta-analysis to compare the diagnostic performance of conventional SPECT (C-SPECT) and cadmium-zinc-telluride (CZT)-SPECT systems in detecting angiographically proven coronary artery disease (CAD).
methodsStudies published between January 2000 and February 2018 were identified by database search. We included studies assessing C-SPECT or CZT-SPECT as a diagnostic test to evaluate patients for the presence of CAD, defined as at least 50% diameter stenosis on invasive coronary angiography. A study was eligible regardless of whether patients were referred for suspected or known CAD.
resultsWe identified 40 eligible articles (25 C-SPECT and 15 CZT-SPECT studies) including 7334 patients (4997 in C-SPECT and 2337 in CZT-SPECT studies). The pooled sensitivity and specificity were 85% and 66% for C-SPECT and 89% and 69% for CZT-SPECT imaging studies. The area under the curve was slightly higher for CZT-SPECT (0.89) compared to C-SPECT (0.83); accordingly, the summary diagnostic OR was 17 for CZT-SPECT and 11 for C-SPECT. The accuracy of the two tests slightly differs between C-SPECT and CZT-SPECT (chi-square 11.28, P < .05). At meta-regression analysis, no significant association between both sensitivity and specificity and demographical and clinical variables considered was found for C-SPECT and CZT-SPECT studies.
conclusionsC-SPECT and CZT-SPECT have good diagnostic performance in detecting angiographic proven CAD, with a slightly higher accuracy for CZT-SPECT. This result supports the use of the novel gamma cameras in clinical routine practices also considering the improvements in acquisition time and radiation exposure reduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.