Evidence map›Paper›PMID 31089953›Full record

ArticleJournal of gastrointestinal cancer2019

Clinical Significance of Serum Vascular Endothelial Growth Factor, Pigment Epithelium-Derived Factor, Tumor Necrosis Factor Alpha, and Progranulin Levels in Patients with Gastric Cancer and Gastric Precancerous Lesions.

Evrim Kahramanoğlu Aksoy, Muhammet Yener Akpınar, Özlem Doğan, Zeynep Göktaş, Ferdane Pirinççi Sapmaz, Gülçin Güler Şimşek, Metin Uzman, Yaşar Nazlıgül

Abstract read
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In one paragraph

Article in Journal of gastrointestinal cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Evrim Kahramanoğlu AksoyDepartment of Gastroenterology, Keçiören Training and Research Hospital, Ankara, Turkey. evrims1979@yahoo.com.ORCID http://orcid.org/0000-0001-8887-3428
Muhammet Yener AkpınarDepartment of Gastroenterology, Keçiören Training and Research Hospital, Ankara, Turkey.
Özlem DoğanDepartment of Biochemistry, Ankara University Faculty of Medicine, Ankara, Turkey.
Zeynep GöktaşDepartment of Dietetics, Nutrition, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey.
Ferdane Pirinççi SapmazDepartment of Gastroenterology, Keçiören Training and Research Hospital, Ankara, Turkey.
Gülçin Güler ŞimşekDepartment of Pathology, Keçiören Training and Research Hospital, Ankara, Turkey.
Metin UzmanDepartment of Gastroenterology, Keçiören Training and Research Hospital, Ankara, Turkey.
Yaşar NazlıgülDepartment of Gastroenterology, Keçiören Training and Research Hospital, Ankara, Turkey.
Ankara University · TRHacettepe University · TRS.B. Keçiören Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe purpose of this study is to evaluate serum levels of vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), tumor necrosis factor alpha (TNF-α), and progranulin in patients with gastric cancer (GC) and precancerous lesions (PCL) and to determine the usefulness of these markers as diagnostic biomarkers in these diseases.

methodA total of 32 GC patients, 35 PCL patients, and 23 healthy controls participated in the study. The serum levels of VEGF, PEDF, TNF-α, and progranulin were measured by enzyme-linked immunosorbent assay (ELISA).

resultsThe mean serum VEGF levels were 30.6 ± 12.98 pg/mL in GC, 18.2 ± 5.72 pg/mL in PCL, and 17.5 ± 5.59 pg/mL in controls. GC VEGF levels were significantly higher than both PCL and control groups (p < 0.001). The mean serum PEDF levels were 1516.1 ± 993.8 pg/mL in GC, 1039.1 ± 1002.3 pg/mL in PCL, and 767.5 ± 661.5 pg/mL in controls. The serum PEDF level in the GC group was significantly higher than that in both PCL and control groups (p = 0.004 and p = 0.038, respectively). The mean serum TNF-α levels were 46.7 ± 14.82 pg/mL in GC, 38.4 ± 11.89 pg/mL in PCL, and 33.8 ± 12.77 pg/mL in controls. There was a significant difference between GC and controls (p = 0.022) in TNF-α levels. The mean serum progranulin levels in GC were 2496.6 ± 737.8 pg/mL, 2332.0 ± 482.1 pg/mL in PCL, and 1288.7 ± 830.9 pg/mL in controls. Progranulin levels in both GC and PCL groups were significantly higher than that in the control group (p < 0.001 for both).

conclusionThere were significant differences among patients with GC and PCL and healthy controls in terms of serum VEGF, PEDF, TNF-α, and progranulin levels.

Indexed as

AdenocarcinomaBiomarkers, TumorCase-Control StudiesDiagnosis, DifferentialEye ProteinsFemaleFollow-Up StudiesHumansMaleMiddle AgedNerve Growth FactorsPigment Epithelium-Derived FactorPrecancerous ConditionsPrognosisProgranulinsROC CurveBiomarkers, TumorEye ProteinsGRN protein, humanNerve Growth FactorsPigment Epithelium-Derived FactorProgranulinsSerpinsTNF protein, humanTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AVEGFA protein, humanGastric atrophyGastric cancerIntestinal metaplasiaPEDFProgranulinTNF-αVEGF

Identifiers

PMID31089953
OpenAlexW2946229594

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.