Evidence map›Paper›PMID 31089892›Full record

ArticlePharmaceutical research2019

Multi-Solvent Microdroplet Evaporation: Modeling and Measurement of Spray-Drying Kinetics with Inhalable Pharmaceutics.

Mani Ordoubadi, Florence K A Gregson, Omar Melhem, David Barona, Rachael E H Miles, Dexter D'Sa, Sandra Gracin, David Lechuga-Ballesteros, Jonathan P Reid, Warren H Finlay and 1 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Pharmaceutical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Mani OrdoubadiDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Florence K A GregsonSchool of Chemistry, University of Bristol, Bristol, UK.
Omar MelhemDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada.
David BaronaDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Rachael E H MilesSchool of Chemistry, University of Bristol, Bristol, UK.
Dexter D'SaPharmaceutical Technology & Development, AstraZeneca R&D South San Francisco, San Francisco, California, USA.
Sandra GracinPharmaceutical Technology & Development, AstraZeneca R&D Gothenburg, Gothenburg, Sweden.
David Lechuga-BallesterosPharmaceutical Technology & Development, AstraZeneca R&D South San Francisco, San Francisco, California, USA.
Jonathan P ReidSchool of Chemistry, University of Bristol, Bristol, UK.
Warren H FinlayDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Reinhard VehringDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada. reinhard.vehring@ualberta.ca.

Funding

Engineering and Physical Sciences Research Council EP/N025245/1Natural Sciences and Engineering Research Council of Canada RGPIN-2016-04111
6 · The paper itself

Abstract

purposeEvaporation and particle formation from multi-solvent microdroplets containing solid excipients pertaining to spray-drying of therapeutic agents intended for lung delivery were studied. Various water and ethanol co-solvent systems containing a variety of actives and excipients (beclomethasone, budesonide, leucine, and trehalose) were considered.

methodsNumerical methods were used to predict the droplet evaporation rates and internal solute transfers, and their results verified and compared with results from two separate experimental setups. In particular, an electrodynamic balance was used to measure the evaporation rates of multicomponent droplets and a monodisperse droplet chain setup collected dried microparticles for further analytical investigations and ultramicroscopy.

resultsThe numerical results are used to explain the different particle morphologies dried from solutions at different co-solvent compositions. The obtained numerical data clearly show that the two parameters controlling the general morphology of a dried particle, namely the Péclet number and the degree of saturation, can change with time in a multi-solvent droplet. This fact complicates product development for such systems. However, this additional complexity vanishes at what we define as the iso-compositional point, which occurs when the solvent ratios and other composition-dependent properties of the droplet remain constant during evaporation, similar to the azeotrope of such systems during distillation.

conclusionsNumerical and experimental analysis of multi-solvent systems indicate that spray-drying near the iso-compositional ratio simplifies the design and process development of such systems.

Indexed as

Nebulizers and VaporizersAdministration, InhalationBeclomethasoneBudesonideDesiccationEthanolExcipientsKineticsLeucinePowdersQuantum TheorySolventsTrehaloseWaterBeclomethasoneBudesonideEthanolExcipientsLeucinePowdersSolventsTrehaloseWaterco-solventsinhaled therapeuticsmicroparticlesmulti-solvent spray-dryingparticle engineering

Identifiers

PMID31089892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.