ArticleInternational journal of colorectal disease2019
The incidence, associated factors, and predictive nomogram for early death in stage IV colorectal cancer.
Article in International journal of colorectal disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 52 citations in OpenAlex.
- A novel risk prediction nomogram for early death in patients with resected synchronous multiple primary colorectal cancer based on the SEER database.International journal of colorectal disease · 2023Trial
- Construction and validation of nomograms combined with novel machine learning algorithms to predict early death of patients with metastatic colorectal cancer.Frontiers in public health · 2022Trial
- Development and validation of a machine learning model for predicting early death in metastatic pancreatic ductal adenocarcinoma: a study based on the SEER database.Translational cancer research · 2026Article
- Colorectal cancer metastasis to the brain: A scoping review of incidence, treatment, and outcomes.World journal of gastrointestinal pathophysiology · 2025Article
- Article
- Value analysis ofTranslational cancer research · 2024Article
- Development and validation of comprehensive nomograms from the SEER database for predicting early mortality in metastatic rectal cancer patients.BMC gastroenterology · 2024Article
- Post-Radiotherapy Exosomal Non-Coding RNA and Hemograms for Early Death Prediction in Patients with Cervical Cancer.International journal of molecular sciences · 2023Article
- A Novel Clinical Nomogram for Predicting Overall Survival in Patients with Emergency Surgery for Colorectal Cancer.Journal of personalized medicine · 2023Article
- Applying machine learning techniques to predict the risk of lung metastases from rectal cancer: a real-world retrospective study.Frontiers in oncology · 2023Article
- A predictive model for early death in elderly colorectal cancer patients: a population-based study.Frontiers in oncology · 2023Article
- Prediction of bone metastasis risk of early breast cancer based on nomogram of clinicopathological characteristics and hematological parameters.Frontiers in oncology · 2023Article
- Development and validation of a clinical survival model for young-onset colorectal cancer with synchronous liver-only metastases: a SEER population-based study and external validation.Frontiers in oncology · 2023Article
- Prognostic factors and individualized nomograms predicting overall survival in stage IV rectal cancer patients with different metastatic status: a SEER-based study.Translational cancer research · 2022Article
- The Impact of Postoperative Complications on Survival after Simultaneous Resection of Colorectal Cancer and Liver Metastases.Healthcare (Basel, Switzerland) · 2022Article
- The nomograms to predict early death among metastatic small-cell lung cancer patients: a retrospective study based on SEER database.Translational cancer research · 2022Article
- Nomogram for predicting postoperative cancer-specific early death in patients with epithelial ovarian cancer based on the SEER database: a large cohort study.Archives of gynecology and obstetrics · 2022Article
- Nomogram for predicting occurrence of synchronous liver metastasis in colorectal cancer: a single-center retrospective study based on pathological factors.World journal of surgical oncology · 2022Article
- Article
- A Predictive Nomogram for Early Death in Pheochromocytoma and Paraganglioma.Frontiers in oncology · 2022Article
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Authors and funding
10 authors at 7 institutions in 3 countries.
Funding
Abstract
purposeThe purpose of the present study was to investigate the incidence and associated factors for early death in stage IV colorectal cancer (CRC) and to construct the predictive nomogram.
methodsPatients with stage IV CRC, who had been diagnosed between 2010 and 2014 in the Surveillance, Epidemiology, and End Results datasets, were eligible for this retrospective cohort study. The univariable and multivariable logistic regression models were conducted to determine the associated factors for early death (survival time ≤ 3 months). The predictive nomogram was constructed and the internal validation was performed.
resultsTen thousand two hundred sixty-three out of 36,461 (28.1%) eligible patients resulted in all causes of early death (25.8% for cancer-specific early death and 2.3% for non-cancer early death). Advanced age, marital status, right colon, poor differentiation, higher N stage, and bone metastasis were positively associated with all causes of early death, cancer-specific early death, and non-cancer early death, while higher T stage, positive carcinoembryonic antigen, and distant metastases (bone, lung, liver, and brain) were only positively associated with all causes of early death and cancer-specific early death. The calibration curve for all causes of early death, cancer-specific early death, and non-cancer early death showed the prediction curve closely approximated at the 45° line and the areas under the curve were 75.7% (95% CI, 74.9-76.4%), 75.9% (95% CI, 75.1-76.6%), and 76.9% (95% CI, 76.3-77.6%), respectively.
conclusionsThe nomogram was calibrated to predict all causes of early death development, cancer-specific early death development, and non-cancer early death development. These findings can be utilized in early screening and to tailor targeted treatment regimens for stage IV CRC patients.
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