Evidence map›Paper›PMID 31089733›Full record

SynthesisAdvances in nutrition (Bethesda, Md.)2019

Association Between Dairy Product Consumption and Colorectal Cancer Risk in Adults: A Systematic Review and Meta-Analysis of Epidemiologic Studies.

Laura Barrubés, Nancy Babio, Nerea Becerra-Tomás, Núria Rosique-Esteban, Jordi Salas-Salvadó

Erratum issuedOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Advances in nutrition (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 63 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 10 pooled it
2.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 10 syntheses or guidelines pooled it, 105 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Laura BarrubésUniversitat Rovira i Virgili, Department of Biochemistry and Biotechnology, Human Nutrition Unit, Sant Joan de Reus Hospital, IISPV, Reus, Spain.
Nancy BabioUniversitat Rovira i Virgili, Department of Biochemistry and Biotechnology, Human Nutrition Unit, Sant Joan de Reus Hospital, IISPV, Reus, Spain.
Nerea Becerra-TomásUniversitat Rovira i Virgili, Department of Biochemistry and Biotechnology, Human Nutrition Unit, Sant Joan de Reus Hospital, IISPV, Reus, Spain.
Núria Rosique-EstebanUniversitat Rovira i Virgili, Department of Biochemistry and Biotechnology, Human Nutrition Unit, Sant Joan de Reus Hospital, IISPV, Reus, Spain.
Jordi Salas-SalvadóUniversitat Rovira i Virgili, Department of Biochemistry and Biotechnology, Human Nutrition Unit, Sant Joan de Reus Hospital, IISPV, Reus, Spain.
Instituto de Salud Carlos III · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dairy product consumption may decrease colorectal cancer (CRC) risk, but very few studies have evaluated the association between different types of dairy products and CRC location. The aim of this systematic review and meta-analysis was to examine the associations between dairy product consumption and CRC incidence. Summary RRs and ORs with 95% CIs were estimated. A total of 15 cohort studies and 14 case-control studies comprising a total of >22,000 cases were included in the quantitative synthesis. The cohort studies showed a consistent significant decrease in CRC risk associated with higher consumption of total dairy products (RR: 0.80; 95% CI: 0.70, 0.91) and total milk (RR: 0.82; 95% CI: 0.76, 0.88) compared with the CRC risk associated with lower consumption. These studies also showed a significant protective association between low-fat milk consumption and CRC (RR: 0.76; 95% CI: 0.66, 0.88), but only for colon cancer (RR: 0.73; 95% CI: 0.61, 0.87). Cheese consumption was inversely associated with the risk of CRC (RR: 0.85; 95% CI: 0.76, 0.96) and proximal colon cancer (RR: 0.74; 95% CI: 0.60, 0.91). No significant associations with CRC were found for the consumption of low-fat dairy products, whole milk, fermented dairy products, or cultured milk. Most of these associations were not supported by the case-control studies. In conclusion, high consumption of total dairy products and total milk was associated with a lower risk of developing CRC at any anatomic location, including the proximal and distal colon and the rectum. Low-fat milk consumption was associated with a lower risk of CRC, but this association was restricted to colon cancer. Cheese consumption was associated with the prevention of CRC, specifically proximal colon cancer. Further studies on larger samples and with longer follow-up periods, along with appropriately designed and executed clinical trials, are warranted to determine whether dairy product consumption affects CRC development.

Indexed as

Dairy ProductsDietFeeding BehaviorAdultAgedAged, 80 and overAnimalsColorectal NeoplasmsDietary FatsFemaleHumansMaleMiddle AgedMilkYoung AdultDietary Fatsadultscase-control studiescheesecolorectal cancerdairymeta-analysismilkprospective studiessystematic reviewyogurt

Identifiers

PMID31089733
PMCPMC6518136
OpenAlexW2945326734

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.