Evidence map›Paper›PMID 31089710›Full record

ArticleSleep2019

Association between insomnia disorder and cognitive function in middle-aged and older adults: a cross-sectional analysis of the Canadian Longitudinal Study on Aging.

Nathan E Cross, Julie Carrier, Ronald B Postuma, Nadia Gosselin, Lisa Kakinami, Cynthia Thompson, Florian Chouchou, Thien Thanh Dang-Vu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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  19. Sleep duration, insomnia and cognitive performance in the Elsa-Brasil cohort: a cross-sectional analysis.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Nathan E CrossInstitut Universitaire de Geriatrie de Montreal and CRIUGM, CIUSSS du Centre-Sud-de-l'Ile-de-Montreal, Montreal, Canada.
Julie CarrierInstitut Universitaire de Geriatrie de Montreal and CRIUGM, CIUSSS du Centre-Sud-de-l'Ile-de-Montreal, Montreal, Canada.
Ronald B PostumaCanadian Sleep and Circadian Network, Montreal, Canada.
Nadia GosselinCanadian Sleep and Circadian Network, Montreal, Canada.
Lisa KakinamiPERFORM Centre, Concordia University, Montreal, Canada.
Cynthia ThompsonCenter for Advanced Research in Sleep Medicine, Hopital du Sacre- Coeur de Montreal, CIUSSS du Nord-de-l'Ile-de-Montreal, Montreal, Canada.
Florian ChouchouInstitut Universitaire de Geriatrie de Montreal and CRIUGM, CIUSSS du Centre-Sud-de-l'Ile-de-Montreal, Montreal, Canada.
Thien Thanh Dang-VuInstitut Universitaire de Geriatrie de Montreal and CRIUGM, CIUSSS du Centre-Sud-de-l'Ile-de-Montreal, Montreal, Canada.
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal · CAInstitut Universitaire de Gériatrie de Montréal · CAConcordia University · CA

Funding

CIHR FDN154291CIHR LSA 9447CIHR MOP 142191CIHR PJT 153115CIHR PJT 156125
6 · The paper itself

Abstract

objectivesThis study examined the differences in cognitive function between middle-aged and older adults with insomnia disorder, insomnia symptoms only (ISO) or no insomnia symptoms (NIS), in the context of other health and lifestyle factors.

methodsTwenty-eight thousand four hundred eighty-five participants >45 years completed questionnaires, physical examinations, and neuropsychological testing across domains of processing speed, memory, and executive functions. An eight-question instrument assessed participants' sleep, defining subjects with insomnia symptoms, probable insomnia disorder (PID), or NIS. The associations between these three groups and cognitive performance were examined with linear regression models adjusted for lifestyle and clinical factors.

resultsPID was identified in 1,068 participants (3.7% of the sample) while 7,813 (27.5%) experienced ISO. Participants with PID exhibited greater proportions of adverse medical and lifestyle features such as anxiety, depression, and diabetes than both other groups. Analyses adjusting for age, sex, education, as well as medical and lifestyle factors demonstrated that adults with PID exhibited declarative memory deficits (Rey Auditory Verbal Learning Test) compared with ISO or NIS. Adults with insomnia symptoms exhibited better performance on a task of mental flexibility than both other groups.

conclusionsThese findings suggest that insomnia disorder in middle-aged and older adults is associated with poorer health outcomes and worse memory performance than adults with insomnia symptoms alone or without any sleep complaints, even after adjustment for comorbidities. The assessment of longitudinal data within this cohort will be critical to understand if insomnia disorder may increase the risk of further cognitive decline.

Indexed as

AgedAgingAnxietyAnxiety DisordersCanadaCognitionComorbidityCross-Sectional StudiesDepressionExecutive FunctionFemaleHealth StatusHumansLongitudinal StudiesMaleMemoryagingCLSAcognitioncohortinsomnia

Identifiers

PMID31089710
PMCPMC6685318
OpenAlexW2944938957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.