ReviewJournal of obesity & metabolic syndrome2019
The Impact of Childhood Obesity on Skeletal Health and Development.
Review in Journal of obesity & metabolic syndrome, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 93 citations in OpenAlex.
- Dietary content and combined training, but not daily physical activity, are associated with 6-month bone mineral changes in adolescents with obesity: A Secondary analysis of the PAC-MAnO trial.European journal of pediatrics · 2024Trial
- The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9-11 Years: The Physical Activity and Nutrition in Children Study.Frontiers in endocrinology · 2022Trial
- Bone Response to High-Intensity Interval Training versus Moderate-Intensity Continuous Training in Adolescents with Obesity.Obesity facts · 2022Trial
- Independent association between relative fat mass and total bone mineral density in U.S. adolescents: a cross-sectional study adjusting for Appendicular Lean Mass Index.Scientific reports · 2026Article
- Updating radiographic parameters for the healthy growing hip: are current parameters still valid?Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2026Article
- The Impact of Modern Lifestyles on Spinal Health in the Pediatric Population: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Life course adiposity and risk of incident osteoporosis: a prospective cohort study from the UK Biobank.Frontiers in endocrinology · 2026Article
- Long-term Western diet feeding impairs hepatic vitamin D metabolism and promotes bone loss in mice.EXCLI journal · 2026Article
- Sarcopenic obesity and skeletal development in children: recent advances.Frontiers in pediatrics · 2026Review
- Patellar and Femoral Bone Morphology Is Associated With Overweight and Sports Participation in Young Adolescents.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Association between lean mass, fat mass, and waist circumference with bone mineral density in Mexican children and adolescents: a cross-sectional study.European journal of pediatrics · 2025Article
- Fat, flames and ultrasounds: the effects of obesity on pediatric joint inflammation.Italian journal of pediatrics · 2025Review
- Obesity and Overweight Conditions in Children and Adolescents (6-18 Years) and Their Impact on Craniofacial Morphology: A Systematic Review.Children (Basel, Switzerland) · 2025Review
- Correlation Analysis between Serum Uric Acid Levels and Bone Mineral Density in Children with Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Assessment of the Mechanical Properties and Fragment Characteristics of a 3D-Printed Forearm Orthosis.Polymers · 2024Article
- High muscular fitness level may positively affect bone strength and body composition in children with overweight and obesity.Archives of osteoporosis · 2024Article
- Bone health following paediatric and adolescent bariatric surgery: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Effects of endocrine disorders on maxillary and mandibular growth in Colombian children and adolescents: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
- Mendelian randomization shows causal effects of birth weight and childhood body mass index on the risk of frailty.Frontiers in public health · 2024Article
- Racial/Ethnic Differences in Bone Mineral Density for Osteoporosis.Current osteoporosis reports · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased risk of fracture identified in obese children has led to a focus on the relationship between fat, bone, and the impact of obesity during skeletal development. Early studies have suggested that despite increased fracture risk, obese children have a higher bone mass. However, body size corrections applied to account for wide variations in size between children led to the finding that obese children have a lower total body and regional bone mass relative to their body size. Advances in skeletal imaging have shifted the focus from quantity of bone in obese children to evaluating the changes in bone microarchitecture that result in a change in bone quality and strength. The findings suggest that bone strength in the appendicular skeleton does not appropriately adapt to an increase in body size which results in a mismatch between bone strength and force from falls. Recent evidence points to differing influences of fat compartments on skeletal development-visceral fat may have a negative impact on bone which may be related to the associated adverse metabolic environment, while marrow adipose tissue may have an independent effect on trabecular bone development in obese children. The role of brown fat has received recent attention, demonstrating differences in the influence on bone mass between white and brown adipose tissues. Obesity results in a shift in growth and pubertal hormones as well as influences bone development through the altered release of adipokines. The change in the hormonal milieu provides an important insight into the skeletal changes observed in childhood obesity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.