Evidence map›Paper›PMID 31089435›Full record

ReviewImmune network2019

Structural Characteristics of Seven IL-32 Variants.

Dong Hyun Sohn, Tam T Nguyen, Sinae Kim, Saerok Shim, Siyoung Lee, Youngmin Lee, Hyunjhung Jhun, Tania Azam, Joohee Kim, Soohyun Kim

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immune network, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

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  15. Association between interleukin-32 polymorphisms and ovarian cancer in the Chinese Han population.International journal of clinical and experimental pathology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Dong Hyun SohnDepartment of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan 50612, Korea.ORCID https://orcid.org/0000-0002-9572-0611
Tam T NguyenLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0000-0001-5806-5817
Sinae KimLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0000-0002-7767-5845
Saerok ShimLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0000-0002-3801-4315
Siyoung LeeYbdYbiotech Research Center, Seoul 08589, Korea.ORCID https://orcid.org/0000-0002-9949-3495
Youngmin LeeDepartment of Medicine, Pusan Paik Hospital, Collage of Medicine, Inje University, Busan 47392, Korea.
Hyunjhung JhunLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0000-0002-3694-9715
Tania AzamYbdYbiotech Research Center, Seoul 08589, Korea.
Joohee KimLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.
Soohyun KimLaboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0000-0002-0322-7935
Konkuk University · KRAdbiotech (South Korea) · KRInje University Busan Paik Hospital · KRPusan National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IL-32 exists as seven mRNA transcripts that can translate into distinct individual IL-32 variants with specific protein domains. These translated protein domains of IL-32 variants code for specific functions that allow for interaction with different molecules intracellularly or extracellularly. The longest variant is IL-32γ possessing 234 amino acid residues with all 11 protein domains, while the shortest variant is IL-32α possessing 131 amino acid residues with three of the protein domains. The first domain exists in 6 variants except IL-32δ variant, which has a distinct translation initiation codon due to mRNA splicing. The last eleventh domain is common domain for all seven IL-32 variants. Numerous studies in different fields, such as inflammation, autoimmunity, pathogen infection, and cancer biology, have claimed the specific biological activity of individual IL-32 variant despite the absence of sufficient data. There are 4 additional IL-32 variants without proper transcripts. In this review, the structural characteristics of seven IL-32 transcripts are described based on the specific protein domains.

Indexed as

IL-32mRNA splicingmRNA transcriptProtein domainsVariants

Identifiers

PMID31089435
PMCPMC6494766
OpenAlexW2943156525

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.