Evidence map›Paper›PMID 31089329›Full record

ArticleStem cells international2019

Mesenchymal Progenitors Derived from Different Locations in Long Bones Display Diverse Characteristics.

Weiguang Lu, Bo Gao, Jing Fan, Pengzhen Cheng, Yaqian Hu, Qiang Jie, Zhuojing Luo, Liu Yang

Open access · goldAbstract read
In one paragraph

Article in Stem cells international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Weiguang LuInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Bo GaoInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Jing FanInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Pengzhen ChengInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yaqian HuInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Qiang JieDepartment of Orthopedic Surgery, Honghui Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, China.
Zhuojing LuoInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Liu YangInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.ORCID 0000-0002-6498-4702
Xijing Hospital · CNXi'an Honghui Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal progenitors within bone marrow have multiple differentiation potential and play an essential role in the maintenance of adult skeleton homeostasis. Mesenchymal progenitors located in bone regions other than the bone marrow also display bone-forming properties. However, owing to the differences in each distinct microenvironment, the mesenchymal characteristics of skeletal progenitor cells within different regions of long bones may show some differences. In order to clearly elucidate these differences, we performed a comparative study on mesenchymal progenitors from different regions of long bones. Here, we isolated mesenchymal progenitors from the periosteum, endosteum, and bone marrow of rat long bones. The three groups exhibited similar cellular morphologies and expressed the typical surface markers associated with mesenchymal stem cells. Interestingly, after cell proliferation assays and bidirectional differentiation analysis, periosteal mesenchymal progenitors showed a higher proliferative ability and adipogenic differentiation potential. In contrast, endosteal mesenchymal progenitors were more prone to osteogenic differentiation. Using

Identifiers

PMID31089329
PMCPMC6476036
OpenAlexW2931883972

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.