Trial reportBone marrow transplantation2019
Psychophysical effects of an exercise therapy during pediatric stem cell transplantation: a randomized controlled trial.
Trial report in Bone marrow transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03956719 (Efficacy and Safety of Autologous Adipose-derived Mesenchymal Stem Cells in the Treatment of Early Knee Osteoarthritis), which is not on this map. Cited by 18 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of Autologous Adipose-derived Mesenchymal Stem Cells in the Treatment of Early Knee Osteoarthritis
Who cites it
18 citing papers in PubMed, 6 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Psychosocial interventions for children and adolescents across the cancer care continuum: A systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Nutrition and physical activity interventions delivered to children and young people during cancer treatment: a systematic literature review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- The effect of physical activity on health-related outcomes in children and adolescents with cancer: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Effect of concurrent training on physical performance and quality of life in children with malignancy: A systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Physical and functional performance assessment in pediatric oncology: a systematic review.Pediatric research · 2022Pooled it
- Effects of Exercise Interventions on Immune Function in Children and Adolescents With Cancer and HSCT Recipients - A Systematic Review.Frontiers in immunology · 2021Pooled it
- Precision-based exercise as a new therapeutic option for children and adolescents with haematological malignancies.Scientific reports · 2020Trial
- Psychological Effects of a Structured Exercise Intervention During Umbilical Cord Blood Transplantation in Children and Adolescents.Integrative cancer therapiesTrial
- Implementing exercise interventions in pediatric oncology: an expert consensus framework from the FORTEe project.Frontiers in oncology · 2026Article
- Precision-based exercise protocols for children with cancer: a methodological approach from the European FORTEe research project.Frontiers in pediatrics · 2026Article
- Article
- Exercise and Childhood Cancer-A Historical Review.Cancers · 2021Review
- Synthesizing the literature on physical activity among children and adolescents affected by cancer: evidence for the international Pediatric Oncology Exercise Guidelines (iPOEG).Translational behavioral medicine · 2021Review
- Adverse Events During Supervised Exercise Interventions in Pediatric Oncology-A Nationwide Survey.Frontiers in pediatrics · 2021Article
- Article
- Lung evaluation in 10 year survivors of pediatric allogeneic hematopoietic stem cell transplantation.European journal of pediatrics · 2019Article
- Reducing Falls in Hospitalized Children and Adolescents with Cancer and Blood Disorders: A Quality Improvement Journey.Pediatric quality & safetyArticle
- Effects of physical exercise for children and adolescents undergoing hematopoietic stem cell transplantation: a systematic review and meta-analysis.Hematology, transfusion and cell therapyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study evaluates the physical and psychosocial effects of an inpatient exercise program for children and adolescents undergoing hematopoietic stem cell transplantation (HSCT). Participants (n = 70) were randomized to an exercise intervention (IG: resistance, endurance, and flexibility training) or a non-exercise control group (CG: mental and relaxation training). Pre- (prior hospital admission; T0) and post- (day of discharge; T1) measurements included maximal isometric knee extension strength (KES; strain gauge force transducer), hand grip strength (HGS; JAMAR dynamometer), distance walked in 6 min (6MWD; 6-minute walk test), quality of life (QoL; KINDL-R) and medical parameters. Fifty-seven patients (IG: n = 28; 11.0 (5-17) years; CG: n = 29; 12.0 (6-18) years) completed the study. During hospitalization the IG and CG attended on average 3.1 (2-4) or 2.9 (0.3-4) training sessions weekly. KES, 6MWD, and HGS significantly decreased (p < 0.05) in the CG, while there were no changes in the IG. Pre- to post-changes in 6MWD and HGS differed significantly between groups (p < 0.05). QoL declined in both groups (p < 0.05). Our results indicate that a moderate exercise program is feasible and might counteract a treatment-associated decline of physical performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.