Evidence map›Paper›PMID 31089253›Full record

Trial reportEuropean journal of clinical nutrition2019

Sesame oil and vitamin E co-administration may improve cardiometabolic risk factors in patients with metabolic syndrome: a randomized clinical trial.

Ali Farajbakhsh, Seyed Mohammad Mazloomi, Mohsen Mazidi, Peyman Rezaie, Marzieh Akbarzadeh, Saeedeh Poor Ahmad, G A Ferns, Richard Ofori-Asenso, Siavash Babajafari

RetractedAbstract readRandomized Controlled TrialRetracted Publication
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Sesame Seeds: A Nutrient-Rich Superfood.Foods (Basel, Switzerland) · 2024
    Review
  6. Effects of sesame (Food science & nutrition · 2023
    Review
  7. Review
  8. Role of vitamins in the metabolic syndrome and cardiovascular disease.Pflugers Archiv : European journal of physiology · 2022
    Review
  9. Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Ali FarajbakhshDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Mohammad MazloomiDepartment of Food Hygiene and Quality Control, School and Research Center of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohsen MazidiDepartment of Biology and Biological Engineering, Food and Nutrition Science, Chalmers University of Technology, SE-41296, Gothenburg, Sweden.
Peyman RezaieAdelaide Medical School, University of Adelaide, Adelaide, Australia.
Marzieh AkbarzadehDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Saeedeh Poor AhmadDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
G A FernsBrighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, UK.
Richard Ofori-AsensoDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Siavash BabajafariDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Jafaris@sums.ac.ir.
Shiraz University of Medical Sciences · IRBrighton and Sussex Medical School · GBChalmers University of Technology · SEMonash University · AUUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMetabolic syndrome (MetS) represents a clustering of metabolic abnormalities that are associated with an increased risk of type 2 diabetes and cardiovascular disease. We aimed to evaluate the effects of sesame oil enriched with vitamin E (vit E), sesame oil alone and sunflower oil on lipid profile, fasting blood glucose (FBG), malondialdehyde (MDA), high-sensitivity C-reactive protein (Hs-CRP), homeostatic model assessment (HOMA-IR), and blood pressure (BP) in patients with MetS. SUBJECTS: Overall, 75 individuals with MetS (aged 30-70 years) participated in this randomized, single-blind controlled trial. Patients were randomly allocated to: (1) Group A (n = 25): sesame oil (30 ml/day) enriched with vit E (400 mg/day), (2) Group B (n = 25): sesame oil (30 ml/day), (3) Group C (n = 25): sunflower oil (30 ml/day). Anthropometric data, dietary intake, blood pressure, and biochemical markers, including fasting serum lipids, FBG, serum insulin, MDA, and hs-CRP were measured at baseline and at week 8.

resultsIn individuals in the sesame oil enriched with vit E group (Group A), there were significant reductions in serum total cholesterol (TC), triglycerides (TG), FBG, HOMA-IR, MDA, hs-CRP, high-density lipoprotein (HDL-C) systolic and diastolic BP (for all the comparison p < 0.02). Similarly, in Group B (taking sesame oil alone), TC, TG, FBG, HOMA-IR, MDA, systolic and diastolic BP were significantly improved (for all the comparison p < 0.025), while there were no significant changes in serum HDL (baseline = 35.9 ± 7.2 mg/dL vs. 36.4 ± 6.2 mg/dL, p = 0.432) and hs-CRP (baseline = 4.38 ± 1.34 mg/dL vs. week 8 = 3.96 ± 1.7 mg/dL, p = 0.057) in second group. No significant changes in any of the studied clinical and anthropometric data were found in Group C (on sunflower oil).

conclusionSesame oil (±vit E) was shown to beneficially affect several cardiometabolic indices (including lipids, FBG, BP, HOMA-IR, and MDA) in patients with MetS.

Indexed as

AdultAgedBlood GlucoseBlood PressureCardiovascular DiseasesC-Reactive ProteinDiabetes Mellitus, Type 2FastingFemaleHumansInsulin ResistanceLipidsMaleMalondialdehydeMetabolic SyndromeMiddle AgedBlood GlucoseC-Reactive ProteinLipidsMalondialdehydeSesame OilVitamin E

Identifiers

PMID31089253
OpenAlexW2945154699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.