ArticleScientific reports2019
Simple Surface Modification of Poly(dimethylsiloxane) via Surface Segregating Smart Polymers for Biomicrofluidics.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
93 citing papers in PubMed, 246 citations in OpenAlex.
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- Bovine Serum Albumin Enhances the Quantitative Performance of Polydimethylsiloxane-Based Chamber Digital PCR by Suppressing Surface Adsorption.Micromachines · 2026Article
- Enhancing the Hemocompatibility of 3D-Printable Silicone Elastomers for Artificial Lung Applications.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Long-Term Hydrophilic, Anti-Clotting, and Anti-Fibrotic Dynamic Covalent Silicone-Based Biomaterials.Advanced healthcare materials · 2026Article
- Phase-Dependent MoSInternational journal of molecular sciences · 2026Article
- Intrinsic and Water-Triggered Hydrophilicity in Tween 20-PDMS Composites for Dynamic and Long-Term Wettability Control.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Beyond Self-Assembly: Bioorthogonal 'Click' Chemistry Strategies for Robust Electrochemical Interfaces in Wearable Biosensors.Biosensors · 2026Review
- Lab-on-a-Chip and Microfluidics Technologies for Nano Drug Delivery.Bioengineering (Basel, Switzerland) · 2026Review
- Reducing Small Molecule Adsorption in a PDMS-Based Microphysiological System of the Female Reproductive Tract via Parylene-C Coating to Improve Mechanistic Studies.ACS applied materials & interfaces · 2026Article
- Tuning Poly(dimethylsiloxane) Hydrophilization and Coating Stability via the Optimization of Polyethylene Glycol Molecular Weight.Polymers · 2025Article
- Characterization of PEG-Modified Composite Membranes for Microfluidic Oxygenator Applications.Micromachines · 2025Article
- Hydrophobic Diffusion Media via Electrografted Organosilicons Enable Competitive Performance in Polymer Electrolyte Fuel Cells.ACS electrochemistry · 2025Article
- Hydrogel-based sweat chloride sensor with high sensitivity and low hysteresis.Biosensors & bioelectronics · 2025Article
- Estradiol and dihydrotestosterone exert sex-specific effects on human fibroblast and endothelial proliferation, bioenergetics, and vasculogenesis.Communications biology · 2025Article
- A Granular Hydrogel-Enabled Wearable Electrochemical Biosensing Platform for Continuous Non-Invasive Sweat Lactate Detection.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- A core-shell microneedle system for stable fibroblast delivery in cell-based therapies.Drug delivery and translational research · 2025Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Poly(dimethylsiloxane) (PDMS) is likely the most popular material for microfluidic devices in lab-on-a-chip and other biomedical applications. However, the hydrophobicity of PDMS leads to non-specific adsorption of proteins and other molecules such as therapeutic drugs, limiting its broader use. Here, we introduce a simple method for preparing PDMS materials to improve hydrophilicity and decrease non-specific protein adsorption while retaining cellular biocompatibility, transparency, and good mechanical properties without the need for any post-cure surface treatment. This approach utilizes smart copolymers comprised of poly(ethylene glycol) (PEG) and PDMS segments (PDMS-PEG) that, when blended with PDMS during device manufacture, spontaneously segregate to surfaces in contact with aqueous solutions and reduce the hydrophobicity without any added manufacturing steps. PDMS-PEG-modified PDMS samples showed contact angles as low as 23.6° ± 1° and retained this hydrophilicity for at least twenty months. Their improved wettability was confirmed using capillary flow experiments. Modified devices exhibited considerably reduced non-specific adsorption of albumin, lysozyme, and immunoglobulin G. The modified PDMS was biocompatible, displaying no adverse effects when used in a simple liver-on-a-chip model using primary rat hepatocytes. This PDMS modification method can be further applied in analytical separations, biosensing, cell studies, and drug-related studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.