ArticleScientific reports2019
Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Epigenetic regulation of DPP4 receptor expression by NONO enables replication of MERS-CoV.bioRxiv : the preprint server for biology · 2026Article
- Operational zoonotic containment of Middle East respiratory syndrome coronavirus in Saudi Arabia: An implementation-oriented One Health genomic framework.Veterinary world · 2026Review
- Saudi Arabia's Middle East respiratory syndrome Coronavirus (MERS-CoV) outbreak: consequences, reactions, and takeaways.Annals of medicine and surgery (2012) · 2024Review
- Article
- A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology.Journal of biomedical semantics · 2022Article
- Repurposable drugs for SARS-CoV-2 and influenza sepsis with scRNA-seq data targeting post-transcription modifications.Precision clinical medicine · 2021Article
- Simultaneous Nosocomial SARS-CoV-2 Outbreaks with Different Patterns of Occurrence in Two General Wards; Experience in a Tertiary Care Hospital in Korea.Journal of Korean medical science · 2021Article
- How lessons learned from the 2015 Middle East respiratory syndrome outbreak affected the response to coronavirus disease 2019 in the Republic of Korea.The Korean journal of internal medicine · 2021Review
- COVID-19 in Healthcare Workers and Serving Safe Healthcare During the Pandemic.Sultan Qaboos University medical journal · 2021Article
- Ontological modeling and analysis of experimentally or clinically verified drugs against coronavirus infection.Scientific data · 2021Article
- Epidemiology of and Risk Factors for Coronavirus Infection in Health Care Workers: A Living Rapid Review.Annals of internal medicine · 2020Review
- Overview: The history and pediatric perspectives of severe acute respiratory syndromes: Novel or just like SARS.Pediatric pulmonology · 2020Review
- CIDO, a community-based ontology for coronavirus disease knowledge and data integration, sharing, and analysis.Scientific data · 2020Article
- Middle East respiratory syndrome.Lancet (London, England) · 2020Review
- Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks.Scientific reports · 2020Article
- Outcome of Oncology Patients Infected With Coronavirus.JCO global oncology · 2020Article
- A comparison of COVID-19, SARS and MERS.PeerJ · 2020Article
- Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome.Methods in molecular biology (Clifton, N.J.) · 2020Article
- A database of geopositioned Middle East Respiratory Syndrome Coronavirus occurrences.Scientific data · 2019Article
- Review
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11 authors.
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Abstract
Since its emergence in 2012, 2,260 cases and 803 deaths due to Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported to the World Health Organization. Most cases were due to transmission in healthcare settings, sometimes causing large outbreaks. We analyzed epidemiologic and clinical data of laboratory-confirmed MERS-CoV cases from eleven healthcare-associated outbreaks in the Kingdom of Saudi Arabia and the Republic of Korea between 2015-2017. We quantified key epidemiological differences between outbreaks. Twenty-five percent (n = 105/422) of MERS cases who acquired infection in a hospital setting were healthcare personnel. In multivariate analyses, age ≥65 (OR 4.8, 95%CI: 2.6-8.7) and the presence of underlying comorbidities (OR: 2.7, 95% CI: 1.3-5.7) were associated with increased mortality whereas working as healthcare personnel was protective (OR 0.07, 95% CI: 0.01-0.34). At the start of these outbreaks, the reproduction number ranged from 1.0 to 5.7; it dropped below 1 within 2 to 6 weeks. This study provides a comprehensive characterization of MERS HCA-outbreaks. Our results highlight heterogeneities in the epidemiological profile of healthcare-associated outbreaks. The limitations of our study stress the urgent need for standardized data collection for high-threat respiratory pathogens, such as MERS-CoV.
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