Evidence map›Paper›PMID 31089142›Full record

ArticleNature communications2019

Association analyses identify 31 new risk loci for colorectal cancer susceptibility.

Philip J Law, Maria Timofeeva, Ceres Fernandez-Rozadilla, Peter Broderick, James Studd, Juan Fernandez-Tajes, Susan Farrington, Victoria Svinti, Claire Palles, Giulia Orlando and 89 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 11 pooled it
26.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 11 syntheses or guidelines pooled it, 270 citations in OpenAlex.

  1. Pooled it
  2. Genome-wide association studies and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2024
    Pooled it
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  4. Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Pooled it
  5. Pooled it
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  7. Large-scale Integrated Analysis of Genetics and Metabolomic Data Reveals Potential Links Between Lipids and Colorectal Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Pooled it
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94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

99 authors at 20 institutions in 22 countries.

Philip J LawDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.ORCID http://orcid.org/0000-0001-9663-4611
Maria TimofeevaColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0002-2503-4253
Ceres Fernandez-RozadillaGrupo de Medicina Xenómica, Fundación Pública Galega de Medicina Xenómica, Instituto de Investigación de Santiago, Santiago de Compostela, 15706, Spain.ORCID http://orcid.org/0000-0001-7330-4804
Peter BroderickDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.ORCID http://orcid.org/0000-0002-8348-5829
James StuddDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.ORCID http://orcid.org/0000-0002-7157-754X
Juan Fernandez-TajesWellcome Centre for Human Genetics, McCarthy Group, Roosevelt Drive, Oxford, OX3 7BN, UK.
Susan FarringtonColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0001-5955-7389
Victoria SvintiColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0001-9926-0416
Claire PallesGastrointestinal Cancer Genetics Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
Giulia OrlandoDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
Amit SudDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.ORCID http://orcid.org/0000-0002-6133-0164
Amy HolroydDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
Steven PenegarDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
Evropi TheodoratouColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Peter Vaughan-ShawColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Harry CampbellColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Lina ZgagaColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0002-9405-9550
Archie CampbellGeneration Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0003-0198-5078
Sarah HarrisGeneration Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Ian J DearyGeneration Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
John StarrGeneration Scotland, Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Laura GatcombeCancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
Maria PinnaCancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
Sarah BriggsCancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
Lynn MartinCancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.ORCID http://orcid.org/0000-0003-3962-389X
Emma JaegerCancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
Archana Sharma-OatesCancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
James EastTranslational Gastroenterology Unit, Nuffield Department. of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.ORCID http://orcid.org/0000-0001-8035-3700
Simon LeedhamWellcome Centre for Human Genetics, McCarthy Group, Roosevelt Drive, Oxford, OX3 7BN, UK.
Roland ArnoldCancer Bioinfomatics Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.
Elaine JohnstoneDepartment of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7LE, UK.
Haitao WangDepartment of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7LE, UK.
David KerrNuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.
Rachel KerrDepartment of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7LE, UK.
Tim MaughanDepartment of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7LE, UK.
Richard KaplanMedical Research Council Clinical Trials Unit, Aviation House, 125 Kingsway, London, WC2B 6NH, UK.ORCID http://orcid.org/0000-0002-0189-8348
Nada Al-TassanDepartment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Saudi Arabia.ORCID http://orcid.org/0000-0001-9076-0334
Kimmo PalinDepartment of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.ORCID http://orcid.org/0000-0002-4621-6128
Ulrika A HänninenDepartment of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.
Tatiana CajusoDepartment of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.
Tomas TanskanenDepartment of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.
Johanna KondelinDepartment of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.
Eevi KaasinenDepartment of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.
Antti-Pekka SarinInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00014, Finland.
Johan G ErikssonFolkhälsan Research Centre, 00250, Helsinki, Finland.
Harri RissanenNational Institute for Health and Welfare, Helsinki, 00271, Finland.
Paul KnektNational Institute for Health and Welfare, Helsinki, 00271, Finland.
Eero PukkalaFinnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland, and Faculty of Social Sciences, University of Tampere, Tampere, 33014, Finland.
Pekka JousilahtiNational Institute for Health and Welfare, Helsinki, 00271, Finland.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, 00271, Finland.ORCID http://orcid.org/0000-0001-7563-5324
Samuli RipattiInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00014, Finland.
Aarno PalotieInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00014, Finland.
Laura Renkonen-SinisaloDepartment of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki, 00029, Finland.
Anna LepistöDepartment of Surgery, Abdominal Center, Helsinki University Hospital, Helsinki, 00029, Finland.
Jan BöhmDepartment of Pathology, Central Finland Central Hospital, Jyväskylä, 40620, Finland.
Jukka-Pekka MecklinDepartment of Surgery, Jyväskylä Central Hospital, Jyväskylä, 40620, Finland.
Daniel D BuchananColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, 3010, Australia.ORCID http://orcid.org/0000-0003-2225-6675
Aung-Ko WinCentre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, 3010, Australia.ORCID http://orcid.org/0000-0002-2794-5261
John HopperCentre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, 3010, Australia.
Mark E JenkinsCentre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, 3010, Australia.ORCID http://orcid.org/0000-0002-8964-6160
Noralane M LindorDepartment of Health Sciences Research, Mayo Clinic, Scottsdale, AZ, 85259, USA.
Polly A NewcombCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Steven GallingerMount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute, Toronto, ON M5G 1X5, Canada.
David DugganTranslational Genomics Research Institute (TGen), An Affiliate of City of Hope, Phoenix, AZ, 85004, USA.
Graham CaseyCenter for Public Health Genomics, University of Virginia, Virginia, VA, 22903, USA.
Per HoffmannHuman Genomics Research Group, Department of Biomedicine, University of Basel, Basel, 4031, Switzerland.
Markus M NöthenDepartment of Genomics, Life & Brain Center, University of Bonn, Bonn, 53127, Germany.
Karl-Heinz JöckelInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, 45147, Germany.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID http://orcid.org/0000-0003-2444-3247
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID http://orcid.org/0000-0001-8494-732X
Julian PetoDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Anthony SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
Rosalind A EelesDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.ORCID http://orcid.org/0000-0002-3698-6241
Zsofia Kote-JaraiDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK.
Kenneth MuirDivision of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0001-6429-988X
Nora PashayanDepartment of Applied Health Research, University College London, London, WC1E 7HB, UK.ORCID http://orcid.org/0000-0003-0843-2468
PRACTICAL consortium
Andrea HarkinCancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK.ORCID http://orcid.org/0000-0002-8831-7381
Karen AllanCancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK.
John McQueenCancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK.
James PaulCancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1BD, UK.ORCID http://orcid.org/0000-0001-7367-5816
Timothy IvesonUniversity Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD, UK.
Mark SaundersThe Christie NHS Foundation Trust, Manchester, M20 4BX, UK.
Katja ButterbachDivision of Clinical Epidemiology and Aging Research, Deutsches Krebsforschungszentrum, 69120, Heidelberg, Germany.
Jenny Chang-ClaudeUnit of Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, Deutsches Krebsforschungszentrum, 69120, Heidelberg, Germany.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, Deutsches Krebsforschungszentrum, 69120, Heidelberg, Germany.
Iva KiracDepartment of Surgical Oncology, University Hospital for Tumours, Sestre milosrdnice University Hospital Centre, Zagreb, 10000, Croatia.
Petar MatoševićDepartment of Surgery, University Hospital Center Zagreb, 10000, Zagreb, Croatia.
Philipp HoferDepartment of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0003-2550-6019
Stefanie BrezinaDepartment of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.ORCID http://orcid.org/0000-0001-5238-6900
Andrea GsurDepartment of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.
Jeremy P CheadleDivision of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.ORCID http://orcid.org/0000-0001-9453-8458
Lauri A AaltonenDepartment of Medical and Clinical Genetics, Medicum and Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, 00014, Finland.
Ian TomlinsonCancer Genetics and Evolution Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK.ORCID http://orcid.org/0000-0003-3037-1470
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UK. richard.houlston@icr.ac.uk.ORCID http://orcid.org/0000-0002-5268-0242
Malcolm G DunlopColon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Institute of Cancer Research · GBUniversity of Helsinki · FIUniversity of Birmingham · GBWestern General Hospital · GBUniversity of Cambridge · GBUniversity of Oxford · GBUniversity of Southern California · USCancer Research UK · GBFinnish Institute for Health and Welfare · FIFred Hutch Cancer Center · USGerman Cancer Research Center · DEThe University of Melbourne · AUInstitute of Genetics and Cancer · GBJohn Radcliffe Hospital · GBManchester Academic Health Science Centre · GBMedical University of Vienna · ATNational Cancer Institute · USUniversity Hospital Centre Zagreb · HRAmerican Cancer Society · USBrigham and Women's Hospital · US

Funding

Data sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8M
SEATTLE FAMILIAL COLORECTAL CANCER REGISTRYU01CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1997 to 2007
$14.1M
Epidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4M
Inherited colorectal cancer risk variants: from association to biologyR01CA143237 · NCI · UNIVERSITY OF VIRGINIA · PI CASEY, GRAHAM · 2010 to 2020
$8.4M
Genomic Wide Association Study of Colorectal CancerU01CA122839 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CASEY, GRAHAM · 2006 to 2010
$7.3M
The Colon Cancer Family Registry: SeattleU24CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 2008 to 2011
$7.0M
ADOLESCENT ALCOHOL ABUSE: A TWIN-STUDY PERSPECTIVER37AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2000 to 2009
$2.9M
Imputation-based approach to identify low frequency variants in prostate cancerU01CA188392 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SCHUMACHER, FREDRICK RAY · 2014 to 2016
$1.9M
Twin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3M
Adolescent Alcohol Abuse: A Twin-Study PerspectiveR01AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2013 to 2017
$1.2M
FHCRC High-Performance Computing ClusterS10OD020069 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2015 to 2015
$600k
USE &ABUSE OF ALCOHOL--A BEHAVIOR-GENETICS PERSPECTIVEK05AA000145 · NIAAA · INDIANA UNIVERSITY BLOOMINGTON · PI ROSE, RICHARD JOSEPH · 1992 to 1996
–
Cancer Research UK 10118Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 12076Cancer Research UK 14136Cancer Research UK 16561Cancer Research UK 16563Cancer Research UK 18504Cancer Research UK 18927Cancer Research UK 22804Cancer Research UK 25355Cancer Research UK 25514Cancer Research UK 27327Medical Research Council G0401527Medical Research Council G0600237Medical Research Council G0600329Medical Research Council G1000143Medical Research Council MC_PC_U127527198Medical Research Council MC_U122861325Medical Research Council MC_U127527198Medical Research Council MC_UU_00007/1Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_12023/20Medical Research Council MC_UU_12023/3Medical Research Council MR/K018647/1Medical Research Council MR/K026992/1Medical Research Council MR/M004007/1Medical Research Council MR/M012190/1Medical Research Council MR/M016587/1Medical Research Council MR/N003284/1Medical Research Council MR/N01104X/2Medical Research Council MR/P001106/1NCI NIH HHS R01 CA143237NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA122839NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA188392NCI NIH HHS U19 CA148537NCI NIH HHS U24 CA074794NHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INIAAA NIH HHS K02 AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R37 AA012502NIH HHS S10 OD020069Wellcome Trust
6 · The paper itself

Abstract

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.

Indexed as

Genetic LociGenetic Predisposition to DiseaseAsian PeopleCase-Control StudiesColorectal NeoplasmsDatasets as TopicFemaleGenome-Wide Association StudyHumansInheritance PatternsMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsWhite People

Identifiers

PMID31089142
PMCPMC6517433
OpenAlexW2944046200

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.