Evidence map›Paper›PMID 31088971›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Synthesis of polypeptides via bioinspired polymerization of in situ purified

Ziyuan Song, Hailin Fu, Jiang Wang, Jingshu Hui, Tianrui Xue, Lazaro A Pacheco, Haoyuan Yan, Ryan Baumgartner, Zhiyu Wang, Yingchun Xia and 7 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
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  9. Article
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  11. Article
  12. Aqueous microdroplets enable abiotic synthesis and chain extension of unique peptide isomers from free amino acids.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  13. Article
  14. Article
  15. Recent Advances in Poly(α-Biomolecules · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ziyuan SongDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.ORCID 0000-0002-3165-3712
Hailin FuDepartment of Chemistry, University of Connecticut, Storrs, CT 06269.
Jiang WangDepartment of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Jingshu HuiDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Tianrui XueDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Lazaro A PachecoDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Haoyuan YanDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Ryan BaumgartnerDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Zhiyu WangDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Yingchun XiaDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Xuefang WangDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Lichen YinInstitute of Functional Nano & Soft Materials, Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Collaborative Innovation Center of Suzhou Nano Science & Technology, Soochow University, 215123 Suzhou, China.
Chongyi ChenDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Joaquín Rodríguez-LópezDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
Andrew L FergusonInstitute for Molecular Engineering, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-8829-9726
Yao LinDepartment of Chemistry, University of Connecticut, Storrs, CT 06269; yao.lin@uconn.edu jianjunc@illinois.edu.
Jianjun ChengDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801; yao.lin@uconn.edu jianjunc@illinois.edu.

Funding

Precision nanotherapeutics for cancer treatmentR01CA207584 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI FAN, TIMOTHY M · 2017 to 2021
$2.0M
NCI NIH HHS R01 CA207584
6 · The paper itself

Abstract

Ribozymes synthesize proteins in a highly regulated local environment to minimize side reactions caused by various competing species. In contrast, it is challenging to prepare synthetic polypeptides from the polymerization of

Indexed as

PeptidesPolymerizationAmino AcidsAnhydridesKineticsMethylene ChlorideModels, BiologicalMolecular WeightPeptide BiosynthesisWaterAmino AcidsAnhydridesMethylene ChloridePeptidesWaterbioinspired polymerizationin situ purificationN-carboxyanhydridepolypeptidesegregation

Identifiers

PMID31088971
PMCPMC6561217

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.