Evidence map›Paper›PMID 31088909›Full record

ArticleMolecular cancer research : MCR2019

Activation of PPARγ in Myeloid Cells Promotes Progression of Epithelial Lung Tumors through TGFβ1.

Trisha R Sippel, Amber M Johnson, Howard Y Li, Dwight Hanson, Teresa T Nguyen, Bonnie L Bullock, Joanna M Poczobutt, Jeff W Kwak, Emily K Kleczko, Mary C Weiser-Evans and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Dual function of activated PPARγ by ligands on tumor growth and immunotherapy.Medical oncology (Northwood, London, England) · 2024
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. TGFβ-Directed Therapeutics: 2020.Pharmacology & therapeutics · 2021
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Trisha R Sippel *Department of Medicine, University of Colorado, Denver, Aurora, Colorado.
Amber M Johnson *Department of Medicine, University of Colorado, Denver, Aurora, Colorado.ORCID 0000-0002-5392-8705
Howard Y LiDepartment of Medicine, University of Colorado, Denver, Aurora, Colorado.ORCID 0000-0002-1230-2941
Dwight HansonDepartment of Medicine, University of Colorado, Denver, Aurora, Colorado.
Teresa T NguyenDepartment of Medicine, University of Colorado, Denver, Aurora, Colorado.ORCID 0000-0002-7211-4176
Bonnie L BullockDepartment of Medicine, University of Colorado, Denver, Aurora, Colorado.ORCID 0000-0002-1580-0292
Joanna M PoczobuttDepartment of Medicine, University of Colorado, Denver, Aurora, Colorado.
Jeff W KwakDepartment of Medicine, University of Colorado, Denver, Aurora, Colorado.
Emily K KleczkoDepartment of Medicine, University of Colorado, Denver, Aurora, Colorado.ORCID 0000-0003-4254-5415
Mary C Weiser-EvansDepartment of Medicine, University of Colorado, Denver, Aurora, Colorado.
Raphael A NemenoffDepartment of Medicine, University of Colorado, Denver, Aurora, Colorado. emenoff@ucdenver.edu.ORCID 0000-0002-2369-2535
University of Colorado Denver · USVeterans Health Administration · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Tissue Bank and Biomarkers CoreP50CA058187 · NCI · UNIVERSITY OF COLORADO DENVER · PI MILLER, YORK E · 1992 to 2018
$43.8M
Training in Translational Research of Lung, Head and Neck CancerT32CA174648 · NCI · UNIVERSITY OF COLORADO DENVER · PI KARAM, SANA D · 2013 to 2022
$4.2M
Preroxisome Proliferator-Activated Receptors in lung CancerR01CA108610 · NCI · UNIVERSITY OF COLORADO DENVER · PI NEMENOFF, RAPHAEL A. · 2004 to 2015
$2.9M
Effects of Complement on the Tumor Microenvironment in Lung CancerR01CA236222 · NCI · UNIVERSITY OF COLORADO DENVER · PI NEMENOFF, RAPHAEL A., THURMAN, JOSHUA M · 2019 to 2023
$2.0M
Role of cPLA2 in Lung Cancer: Microenvironment vs Tumor CellsR01CA103618 · NCI · UNIVERSITY OF COLORADO DENVER · PI NEMENOFF, RAPHAEL A. · 2003 to 2010
$1.9M
Eicosanoids in Lung Cancer: Progression and MetastasisR01CA162226 · NCI · UNIVERSITY OF COLORADO DENVER · PI NEMENOFF, RAPHAEL A. · 2013 to 2017
$1.6M
BLRD VA IK2 BX001282NCI NIH HHS P30 CA046934NCI NIH HHS P50 CA058187NCI NIH HHS R01 CA103618NCI NIH HHS R01 CA108610NCI NIH HHS R01 CA162226NCI NIH HHS R01 CA236222NCI NIH HHS T32 CA174648
6 · The paper itself

Abstract

Lung cancer is a heterogeneous disease in which patient-specific treatments are desirable and the development of targeted therapies has been effective. Although mutations in

Indexed as

Epithelial-Mesenchymal TransitionAdenocarcinoma of LungAnimalsCarcinoma, Lewis LungCell ProliferationDisease ProgressionLung NeoplasmsMiceMutationMyeloid CellsPPAR gammaProto-Oncogene Proteins p21(ras)Receptors, Transforming Growth Factor betaSignal TransductionTransforming Growth Factor beta1Tumor MicroenvironmentHras protein, mousePPAR gammaProto-Oncogene Proteins p21(ras)Receptors, Transforming Growth Factor betaTgfb1 protein, mouseTransforming Growth Factor beta1

Identifiers

PMID31088909
PMCPMC7439607
OpenAlexW2945971888

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.