Evidence map›Paper›PMID 31088907›Full record

ArticleMolecular cancer research : MCR2019

The Codon 72

Jun-Hung Cho, Bhaumik Patel, Santosh Bonala, Hossein Mansouri, Sasikanth Manne, Surya Kumari Vadrevu, Shanawaz Ghouse, Che-Pei Kung, Maureen E Murphy, Aristotelis Astrinidis and 4 more

Open access · greenAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Current insight into the molecular mechanisms of lymphangioleiomyomatosis.American journal of respiratory cell and molecular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Jun-Hung Cho *Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center, Abilene, Texas.
Bhaumik Patel *Department of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center, Abilene, Texas.
Santosh BonalaDepartment of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center, Abilene, Texas.
Hossein MansouriDepartment of Mathematics and Statistics, Texas Tech University, Broadway and Boston, Lubbock, Texas.ORCID 0000-0001-7921-8501
Sasikanth ManneDepartment of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center, Abilene, Texas.
Surya Kumari VadrevuDepartment of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center, Abilene, Texas.ORCID 0000-0003-1908-3611
Shanawaz GhouseDepartment of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center, Abilene, Texas.
Che-Pei KungProgram in Molecular and Cellular Oncogenesis, Wistar Institute, Philadelphia, Pennsylvania.ORCID 0000-0002-1150-4998
Maureen E MurphyProgram in Molecular and Cellular Oncogenesis, Wistar Institute, Philadelphia, Pennsylvania.
Aristotelis AstrinidisDivision of Nephrology, Department of Pediatrics, University of Tennessee Health Sciences Center, and Tuberous Sclerosis Complex Center of Excellence, Le Bonheur Children's Hospital, Memphis, Tennessee.ORCID 0000-0001-7098-1391
Elizabeth P HenskeDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
David J KwiatkowskiDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-5668-5219
Maciej M MarkiewskiDepartment of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center, Abilene, Texas. magdalena.karbowniczek@ttuhsc.edu maciej.markiewski@ttuhsc.edu.
Magdalena KarbowniczekDepartment of Immunotherapeutics and Biotechnology, School of Pharmacy, Texas Tech University Health Science Center, Abilene, Texas. magdalena.karbowniczek@ttuhsc.edu maciej.markiewski@ttuhsc.edu.
Texas Tech University · USThe Wistar Institute · USBrigham and Women's Hospital · USLe Bonheur Children's Hospital · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9M
Research Resource for Human Organs and Tissues (U42)U42OD011158 · OD · NATIONAL DISEASE RESEARCH INTERCHANGE · PI BELL, THOMAS J · 2012 to 2025
$25.0M
Functional Analysis of p53 Polymorphic Variants - Diversity SupplementR01CA102184 · NCI · WISTAR INSTITUTE · PI Maureen E. Murphy · 2005 to 2026
$7.4M
p53 Variants in Cancer Risk and TherapyR01CA201430 · NCI · WISTAR INSTITUTE · PI MURPHY, MAUREEN E. · 2016 to 2020
$2.2M
Targeting the Premetastatic Niche by Antiangiogenic ImmunotherapyR01CA190209 · NCI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI MARKIEWSKI, MACIEJ MICHAL · 2016 to 2020
$1.7M
NCI NIH HHS P01 CA120964NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA102184NCI NIH HHS R01 CA190209NCI NIH HHS R01 CA201430NIH HHS U42 OD011158
6 · The paper itself

Abstract

We discovered that 90.3% of patients with angiomyolipomas, lymphangioleiomyomatosis (LAM), and tuberous sclerosis complex (TSC) carry the arginine variant of codon 72 (R72) of

Indexed as

Polymorphism, Single NucleotideAngiomyolipomaAnimalsCarcinogenesisCell MovementEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansKidney NeoplasmsMiceMutationNodal ProteinReceptor, Notch1Tuberous SclerosisTuberous Sclerosis Complex 1 ProteinTumor Cells, CulturedNodal ProteinReceptor, Notch1TP53 protein, humanTrp53 protein, mouseTSC1 protein, humanTsc1 protein, mouseTuberous Sclerosis Complex 1 ProteinTumor Suppressor Protein p53

Identifiers

PMID31088907
PMCPMC6677621
OpenAlexW2944986653

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.