Trial reportCanadian family physician Medecin de famille canadien2019
Buprenorphine in the emergency department: Randomized clinical controlled trial of clonidine versus buprenorphine for the treatment of opioid withdrawal.
Trial report in Canadian family physician Medecin de famille canadien, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03174067 (Buprenorphine in the Emergency Department), which is not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Buprenorphine in the Emergency Department: Buprenorphine Versus Clonidine for Opioid Withdrawal
Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Facilitating rapid access to addiction treatment: a randomized controlled trial.Addiction science & clinical practice · 2021Trial
- Drug Use After Emergency Department-Initiated Injectable Buprenorphine: A Secondary Analysis of the ED-INNOVATION Ancillary Safety and Feasibility Trial.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026Article
- The Financial Sustainability of Programs to Initiate Medications for Opioid Use Disorder in Emergency Department Settings.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026Article
- Emergency department buprenorphine program: staff concerns and recommended implementation strategies.Implementation science communications · 2024Article
- National Institute on Drug Abuse Clinical Trials Network Meeting Report: Advancing Emergency Department Initiation of Buprenorphine for Opioid Use Disorder.Annals of emergency medicine · 2023Article
- French-Canadian Translation and Cultural Adaptation of the Clinical Opiate Withdrawal Scale: The COWS-FC.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2022Article
- Implementing a Novel Statewide Network to Support Emergency Department-initiated Buprenorphine Treatment.The western journal of emergency medicine · 2022Review
- Emergency department-based efforts to offer medication treatment for opioid use disorder: What can we learn from current approaches?Journal of substance abuse treatment · 2021Review
- Prescribing Buprenorphine for Opioid Use Disorders in the ED: A Review of Best Practices, Barriers, and Future Directions.Open access emergency medicine : OAEM · 2020Review
- Prioritized Research for the Prevention, Treatment, and Reversal of Chronic Disease: Recommendations From the Lifestyle Medicine Research Summit.Frontiers in medicine · 2020Review
- Emergency Department Initiation of Buprenorphine for Opioid Use Disorder: Current Status, and Future Potential.CNS drugs · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare buprenorphine to clonidine for the treatment of opioid withdrawal in the emergency department (ED) and to study the effect assigned treatment medication had on longer-term addiction treatment outcomes.
designRandomized controlled trial.
settingToronto, Ont.
participantsTwenty-six patients presenting to the ED while in opioid withdrawal or soon to be in opioid withdrawal.
main outcome measuresPatients were randomized to receive either clonidine or buprenorphine treatment. Both groups also received a corresponding discharge prescription and information on how to follow up in the addictions rapid access clinic (RAC) within a few days. Participants were followed for 1 month with respect to attendance at the RAC and to opioid agonist treatment status. Outcome measures included attendance at the RAC within 5 days of the initial ED visit and opioid agonist treatment status at 1 month (as determined by clinic attendance or self-report during a follow-up telephone interview).
resultsParticipants who received buprenorphine in the ED were more likely to be receiving opioid agonist treatment at the 1-month mark compared with those participants who received clonidine to treat their withdrawal (
conclusionWhen opioid withdrawal is treated with buprenorphine in the ED, patients are more likely to be receiving opioid agonist treatment and connected with addiction treatment 1 month later. TRIAL REGISTRATION NUMBER: NCT03174067 (ClinicalTrials.gov).
Indexed as
Identifiers
31088887PMC6516696W2946051957What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.