Evidence map›Paper›PMID 31088860›Full record

ArticleRNA (New York, N.Y.)2019

Human PRPF40B regulates hundreds of alternative splicing targets and represses a hypoxia expression signature.

Paolo Alberto Lorenzini, Resilind Su Ern Chew, Cheryl Weiqi Tan, Jing Yen Yong, Fan Zhang, Jie Zheng, Xavier Roca

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  6. Review
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  12. Impacts and mechanisms of alternative mRNA splicing in cancer metabolism, immune response, and therapeutics.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Review
  13. Review
  14. Review
  15. Article
  16. RNA biology · 2021
    Article
  17. Article
  18. Hypoxia-induced alternative splicing: the 11th Hallmark of Cancer.Journal of experimental & clinical cancer research : CR · 2020
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Paolo Alberto LorenziniSchool of Biological Sciences, Nanyang Technological University, 637551 Singapore, Singapore.
Resilind Su Ern ChewSchool of Biological Sciences, Nanyang Technological University, 637551 Singapore, Singapore.
Cheryl Weiqi TanSchool of Biological Sciences, Nanyang Technological University, 637551 Singapore, Singapore.
Jing Yen YongSchool of Biological Sciences, Nanyang Technological University, 637551 Singapore, Singapore.
Fan ZhangSchool of Computer Science and Engineering, Nanyang Technological University, 637551 Singapore, Singapore.
Jie ZhengSchool of Computer Science and Engineering, Nanyang Technological University, 637551 Singapore, Singapore.
Xavier RocaSchool of Biological Sciences, Nanyang Technological University, 637551 Singapore, Singapore.
Nanyang Technological University · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Altered splicing contributes to the pathogenesis of human blood disorders including myelodysplastic syndromes (MDS) and leukemias. Here we characterize the transcriptomic regulation of PRPF40B, which is a splicing factor mutated in a small fraction of MDS patients. We generated a full

Indexed as

Alternative SplicingGene Regulatory NetworksCarrier ProteinsCell HypoxiaCRISPR-Cas SystemsDown-RegulationGene Expression ProfilingGene Expression Regulation, NeoplasticGene Knockout TechniquesHumansHypoxia-Inducible Factor 1, alpha SubunitK562 CellsKruppel-Like Transcription FactorsLeukemia, Myeloid, AcuteMutationMyelodysplastic SyndromesCarrier Proteinserythroid Kruppel-like factorHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitKruppel-Like Transcription FactorsPRPF40B protein, humanacute myeloid leukemiaalternative splicinghypoxiamyelodysplastic syndromesPRPF40B

Identifiers

PMID31088860
PMCPMC6633195
OpenAlexW2945356197

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.