Evidence map›Paper›PMID 31088859›Full record

ArticleThe Journal of cell biology2019

Junctional tumor suppressors interact with 14-3-3 proteins to control planar spindle alignment.

Yu-Ichiro Nakajima, Zachary T Lee, Sean A McKinney, Selene K Swanson, Laurence Florens, Matthew C Gibson

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

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  9. Evidence for a nuclear role forMolecular biology of the cell · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Yu-Ichiro NakajimaStowers Institute for Medical Research, Kansas City, MO yuichiro.nakajima.d2@tohoku.ac.jp.ORCID 0000-0002-1823-5989
Zachary T LeeStowers Institute for Medical Research, Kansas City, MO.
Sean A McKinneyStowers Institute for Medical Research, Kansas City, MO.
Selene K SwansonStowers Institute for Medical Research, Kansas City, MO.ORCID 0000-0002-2461-2744
Laurence FlorensStowers Institute for Medical Research, Kansas City, MO.ORCID 0000-0002-9310-6650
Matthew C GibsonStowers Institute for Medical Research, Kansas City, MO.ORCID 0000-0001-5588-8842
Stowers Institute for Medical Research · US

Funding

Mitotic Rounding and Planar Spindle Alignment in Proliferating EpitheliaR01GM111733 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI GIBSON, MATTHEW C · 2015 to 2019
$1.5M
NIGMS NIH HHS R01 GM111733
6 · The paper itself

Abstract

Proper orientation of the mitotic spindle is essential for cell fate determination, tissue morphogenesis, and homeostasis. During epithelial proliferation, planar spindle alignment ensures the maintenance of polarized tissue architecture, and aberrant spindle orientation can disrupt epithelial integrity. Nevertheless, in vivo mechanisms that restrict the mitotic spindle to the plane of the epithelium remain poorly understood. Here we show that the junction-localized tumor suppressors Scribbled (Scrib) and Discs large (Dlg) control planar spindle orientation via Mud and 14-3-3 proteins in the

Indexed as

Cell Polarity14-3-3 ProteinsAnimalsDrosophila melanogasterDrosophila ProteinsEpithelial CellsMorphogenesisSpindle ApparatusTumor Suppressor ProteinsWings, Animal14-3-3 ProteinsDrosophila ProteinsTumor Suppressor Proteins

Identifiers

PMID31088859
PMCPMC6548121
OpenAlexW2945777154

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.