Evidence map›Paper›PMID 31088857›Full record

ArticleMolecular & cellular proteomics : MCP2019

Interactive Peptide Spectral Annotator: A Versatile Web-based Tool for Proteomic Applications.

Dain R Brademan, Nicholas M Riley, Nicholas W Kwiecien, Joshua J Coon

Abstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed.

  1. Late-Stage Posttranslational Assembly of Fosfazinomycins.bioRxiv : the preprint server for biology · 2026
    Article
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  7. Structure and Activity of Class II Lanthipeptides From a Thermophilic Bacterium.Chembiochem : a European journal of chemical biology · 2026
    Article
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  10. Investigating the Efficiency of Ultraviolet Photodissociation in Peptides Modified withJournal of the American Society for Mass Spectrometry · 2026
    Article
  11. Article
  12. TMPRSS2-mediated coronavirus spike activation and inhibition.Nature structural & molecular biology · 2026
    Article
  13. Co-opting the bacterial lipoprotein pathway for the biosynthesis of lipidated macrocyclic peptides.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. Structure, biosynthesis, and bioactivity of nostolysamides.bioRxiv : the preprint server for biology · 2026
    Article
  15. Article
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  17. The protease cathepsin K can debulk the cancer glycocalyx.The Journal of biological chemistry · 2026
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  18. Article
  19. Article
  20. Article

53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dain R BrademanDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706; Genome Center of Wisconsin, Madison, WI 53706.
Nicholas M RileyDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706; Genome Center of Wisconsin, Madison, WI 53706.
Nicholas W KwiecienDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706; Genome Center of Wisconsin, Madison, WI 53706.
Joshua J CoonDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706; Morgridge Institute for Research, Madison, WI 53715; Genome Center of Wisconsin, Madison, WI 53706; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706. Electronic address: jcoon@chem.wisc.edu.

Funding

Institutional Training in the Genomic SciencesT32HG002760 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI Qiongshi Lu · 2003 to 2026
$17.7M
TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1M
Structure, Function and Regulation of the ProteomeR35GM118110 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$9.1M
Uniting Mass Spectrometry and Glycoscience to Investigate Cancer BiologyK00CA212454 · NCI · STANFORD UNIVERSITY · PI RILEY, NICHOLAS M · 2018 to 2021
$331k
Uniting Mass Spectrometry and Glycoscience to Investigate Cancer BiologyF99CA212454 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI RILEY, NICHOLAS M · 2016 to 2017
$65k
NCI NIH HHS F99 CA212454NCI NIH HHS K00 CA212454NHGRI NIH HHS T32 HG002760NIGMS NIH HHS P41 GM108538NIGMS NIH HHS R35 GM118110
6 · The paper itself

Abstract

Here we present IPSA, an innovative web-based spectrum annotator that visualizes and characterizes peptide tandem mass spectra. A tool for the scientific community, IPSA can visualize peptides collected using a wide variety of experimental and instrumental configurations. Annotated spectra are customizable via a selection of interactive features and can be exported as editable scalable vector graphics to aid in the production of publication-quality figures. Single spectra can be analyzed through provided web forms, whereas data for multiple peptide spectral matches can be uploaded using the Proteomics Standards Initiative file formats mzTab, mzIdentML, and mzML. Alternatively, peptide identifications and spectral data can be provided using generic file formats. IPSA provides supports for annotating spectra collecting using negative-mode ionization and facilitates the characterization of experimental MS/MS performance through the optional export of fragment ion statistics from one to many peptide spectral matches. This resource is made freely accessible at http://interactivepeptidespectralannotator.com, whereas the source code and user guides are available at https://github.com/coongroup/IPSA for private hosting or custom implementations.

Indexed as

Databases, ProteinInternetPeptidesProteomicsSaccharomyces cerevisiae ProteinsSoftwareTandem Mass SpectrometryPeptidesSaccharomyces cerevisiae ProteinsBioinformaticsBioinformatics softwareData evaluationMass SpectrometryPeptides*Quality control and metricsTandem Mass Spectrometry

Identifiers

PMID31088857
PMCPMC6692776

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.