Evidence map›Paper›PMID 31088837›Full record

ArticleCancer research2019

Magnetic Resonance Imaging Is More Sensitive Than PET for Detecting Treatment-Induced Cell Death-Dependent Changes in Glycolysis.

Richard L Hesketh, Jiazheng Wang, Alan J Wright, David Y Lewis, Alice E Denton, Richard Grenfell, Jodi L Miller, Robert Bielik, Marcel Gehrung, Maria Fala and 4 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 51 citations in OpenAlex.

  1. Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using HyperpolarizedAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. RadioFlow Cytometry Reveals That [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  4. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Nature biomedical engineering · 2023
    Article
  11. Hyperpolarized Carbon-13 MRI in Breast Cancer.Diagnostics (Basel, Switzerland) · 2023
    Review
  12. Reproducibility of 3D MRSI for imaging human brain glucose metabolism using direct (medRxiv : the preprint server for health sciences · 2023
    Article
  13. Article
  14. Article
  15. AJournal of magnetic resonance (San Diego, Calif. : 1997) · 2022
    Article
  16. [HyperpolarizedRadiologie (Heidelberg, Germany) · 2022
    Review
  17. Article
  18. Review
  19. Article
  20. Specialized computational methods for denoising, BMagnetic resonance in medicine · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Richard L HeskethCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.
Jiazheng WangCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.
Alan J WrightCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0002-4577-5681
David Y LewisCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0001-9329-1326
Alice E DentonLymphocyte Signalling and Development, Babraham Hall House, Babraham, Cambridge, United Kingdom.ORCID 0000-0002-4580-3443
Richard GrenfellCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.
Jodi L MillerCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0001-6870-204X
Robert BielikCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0002-3674-4795
Marcel GehrungCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.ORCID 0000-0001-6915-9552
Maria FalaCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.
Susana RosCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.
Bangwen XieCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.
De-En HuCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom.
Kevin M BrindleCRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom. kmb1001@cam.ac.uk.
Cancer Research UK Cambridge Center · GBBabraham Institute · GBUniversity of Cambridge · GB

Funding

Cancer Research UK 16465Cancer Research UK 17242Cancer Research UK 25006Cancer Research UK 28289Cancer Research UK A16465Cancer Research UK A17242
6 · The paper itself

Abstract

Metabolic imaging has been widely used to measure the early responses of tumors to treatment. Here, we assess the abilities of PET measurement of [

Indexed as

AdenocarcinomaAnimalsAntineoplastic AgentsCarbon IsotopesCell DeathCell Line, TumorColorectal NeoplasmsFemaleFluorodeoxyglucose F18GlycolysisHeterograftsHumansLactic AcidMagnetic Resonance ImagingMice, Inbred BALB CMice, NudeAntineoplastic AgentsCarbon IsotopesFluorodeoxyglucose F18Lactic AcidPyruvic AcidRadiopharmaceuticalsReceptors, TNF-Related Apoptosis-Inducing Ligand

Identifiers

PMID31088837
PMCPMC6640042
OpenAlexW2945063387

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.