ArticleCancer prevention research (Philadelphia, Pa.)2019
Losartan and Vitamin D Inhibit Colonic Tumor Development in a Conditional Apc-Deleted Mouse Model of Sporadic Colon Cancer.
Urszula Dougherty, Reba Mustafi, Haider I Haider, Abdurahman Khalil, Jeffrey S Souris, Loren Joseph, John Hart, Vani J Konda, Wei Zhang, Joel Pekow and 2 more
Article in Cancer prevention research (Philadelphia, Pa.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors at 4 institutions in 1 country.
Urszula DoughertyDepartment of Medicine, University of Chicago, Chicago, Illinois.
Reba MustafiDepartment of Medicine, University of Chicago, Chicago, Illinois.
Haider I HaiderDepartment of Medicine, University of Chicago, Chicago, Illinois.
Abdurahman KhalilDepartment of Medicine, University of Chicago, Chicago, Illinois.
Jeffrey S SourisDepartment of Radiology, University of Chicago, Chicago, Illinois.
Loren JosephDepartment of Pathology, Beth Israel, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-9503-4689
John HartDepartment of Pathology, University of Chicago, Chicago, Illinois.
Vani J KondaDepartment of Medicine, University of Chicago, Chicago, Illinois.
Wei ZhangDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Joel PekowDepartment of Medicine, University of Chicago, Chicago, Illinois.
Yan Chun LiDepartment of Medicine, University of Chicago, Chicago, Illinois.ORCID 0000-0001-9937-7630
Marc BissonnetteDepartment of Medicine, University of Chicago, Chicago, Illinois. mbissonn@medicine.bsd.uchicago.edu.
University of Chicago · USUniversity of Illinois Chicago · USBeth Israel Deaconess Medical Center · USNorthwestern University · US
Funding
ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
Development of 5hmC and 5mC biomarkers in cell-free circulating DNA for sensitive colon cancer detection and prognosisU01CA217078 · NCI · UNIVERSITY OF CHICAGO · PI BISSONNETTE, BRUCE MARC, ZHANG, WEI · 2017 to 2021
$3.2M
Roles of ErbB Signaling in Colonic CarcinogenesisR01CA036745 · NCI · UNIVERSITY OF CHICAGO · PI BISSONNETTE, BRUCE MARC · 1985 to 2007
$2.3M
(PQA1) Mechanism of Vitamin D Chemoprevention Against Colon CancerR01CA180087 · NCI · UNIVERSITY OF CHICAGO · PI LI, YAN CHUN · 2013 to 2016
$1.7M
Nanotheranostics for Early Colorectal Cancer Detection and TreatmentR01CA171785 · NCI · UNIVERSITY OF CHICAGO · PI SOURIS, JEFFREY S. · 2013 to 2017
$1.6M
Roles of EGFR and miR-143/miR-145 in Western diet-promoted colonic tumorigenesisR01CA164124 · NCI · UNIVERSITY OF CHICAGO · PI BISSONNETTE, BRUCE MARC · 2012 to 2016
$1.6M
EGFR-VDR signals in diet-promoted inflammation and cancerR21CA141092 · NCI · UNIVERSITY OF CHICAGO · PI BISSONNETTE, BRUCE MARC · 2010 to 2011
Colorectal cancer is a leading cause of cancer deaths. The renin-angiotensin system (RAS) is upregulated in colorectal cancer, and epidemiologic studies suggest RAS inhibitors reduce cancer risk. Because vitamin D (VD) receptor negatively regulates renin, we examined anticancer efficacy of VD and losartan (L), an angiotensin receptor blocker. Control Apc
Indexed as
Disease Models, AnimalAdenomatous Polyposis Coli ProteinAngiotensin II Type 1 Receptor BlockersAnimalsApoptosisCell ProliferationColonic NeoplasmsDrug Therapy, CombinationGene Expression Regulation, NeoplasticHumansLosartanMiceMice, Inbred C57BLMice, KnockoutReceptors, CalcitriolTumor Cells, CulturedAdenomatous Polyposis Coli Proteinadenomatous polyposis coli protein, mouseAngiotensin II Type 1 Receptor BlockersLosartanReceptors, CalcitriolVDR protein, humanVitamin DVitamins
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Losartan and Vitamin D Inhibit Colonic Tumor Development in a Conditional Apc-Deleted Mouse Model of Sporadic Colon Cancer. · full record | OpenQuestion