Evidence map›Paper›PMID 31088651›Full record

ArticleMedical hypotheses2019

Can an amino acid-based oral rehydration solution be effective in managing immune therapy-induced diarrhea?

J D Hendrie, A Chauhan, N R Nelson, L B Anthony

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical hypotheses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. New paradigm of oral rehydration in patients affected by irritable bowel syndrome with chronic diarrhea.World journal of gastrointestinal pharmacology and therapeutics · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

J D HendrieUniversity of Kentucky Markey Cancer Center, 800 Rose St., Lexington, KY 40536, USA.
A ChauhanUniversity of Kentucky Markey Cancer Center, 800 Rose St., Lexington, KY 40536, USA.
N R NelsonUniversity of Kentucky Markey Cancer Center, 800 Rose St., Lexington, KY 40536, USA.
L B AnthonyUniversity of Kentucky Markey Cancer Center, 800 Rose St., Lexington, KY 40536, USA. Electronic address: Lowell.anthony@uky.edu.

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI KATHLEEN L. O'CONNOR · 2013 to 2026
$38.3M
NCI NIH HHS P30 CA177558
6 · The paper itself

Abstract

Immune checkpoint inhibitor (ICPi) therapy has transformed the way we treat cancer. However, its immune related adverse events (irAEs) can be debilitating and life threatening. Immune therapy-induced diarrhea (ITID) is one of the most commonly encountered irAEs and can lead to expensive and prolonged hospitalizations. The current standard of care for grade 3 or 4 ITID involves ICPi discontinuation, the initiation of steroids, and infliximab for refractory disease. This treatment regimen reverses the desired anti-tumor effect of ICPis, can lead to side effects, and is cost-ineffective. We report the first case of the successful treatment of grade 3 ITID with steroids and an amino acid-based oral rehydration solution (AA-ORS), enterade. Research suggests that AA-ORS may be used to reduce diarrhea and adequately hydrate patients, in contrast to glucose-based oral rehydration solutions, which have been implicated as a contributing factor to diarrhea in cancer patients. We hypothesize that an AA-ORS may mitigate ITID via safer and more economically viable means than the current standard of care, but more controlled trials are needed to test this hypothesis.

Indexed as

Administration, OralAmino AcidsAntineoplastic AgentsBicarbonatesClinical Trials as TopicColitisDiarrheaFemaleGlucoseHumansImmunotherapyMiddle AgedNeoplasmsPotassium ChloridePractice Guidelines as TopicRehydration SolutionsAmino AcidsAntineoplastic AgentsBicarbonatesGlucosePotassium ChlorideRehydration SolutionsSodium ChlorideSteroidsWorld Health Organization oral rehydration solutionAdverse eventsAmino acidColitisDiarrheaEnteradeImmune checkpoint inhibitorsImmune therapySupportive care

Identifiers

PMID31088651
PMCPMC9281899

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.