Evidence map›Paper›PMID 31088591›Full record

ArticleThe British journal of psychiatry : the journal of mental science2019

Surface-based shared and distinct resting functional connectivity in attention-deficit hyperactivity disorder and autism spectrum disorder.

Minyoung Jung, Yiheng Tu, Joel Park, Kristen Jorgenson, Courtney Lang, Wenwen Song, Jian Kong

Open access · bronzeAbstract read
In one paragraph

Article in The British journal of psychiatry : the journal of mental science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  12. Challenges in the Differential Classification of Individual Diagnoses from Co-Occurring Autism and ADHD Using Survey Data.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2024
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  20. Evidence from "big data" for the default-mode hypothesis of ADHD: a mega-analysis of multiple large samples.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Minyoung JungAssistant Professor, Research Center for Child Mental Development,University of Fukui,Japan.ORCID 0000-0001-9188-0549
Yiheng TuResearch Fellow, Department of Psychiatry,Massachusetts General Hospital, Harvard Medical School,USA.
Joel ParkResearch Coordinator, Department of Psychiatry,Massachusetts General Hospital, Harvard Medical School,USA.
Kristen JorgensonResearch Coordinator, Department of Psychiatry,Massachusetts General Hospital, Harvard Medical School,USA.
Courtney LangResearch Coordinator, Department of Psychiatry,Massachusetts General Hospital, Harvard Medical School,USA.
Wenwen SongRadiologist,The First Affiliated Hospital of Zhejiang Chinese Medical University,China.
Jian KongAssociated Professor, Department of Psychiatry,Massachusetts General Hospital, Harvard Medical School,USA.
Harvard University · USUniversity of Fukui · JPZhejiang Chinese Medical University · CN

Funding

Neuromodulation of placebo and nocebo effectsR01AT008563 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2015 to 2019
$3.9M
The Neurobiology of Placebo and Nocebo Effects: A Brain Imaging StudyR01AT006364 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2011 to 2015
$3.6M
Modulation effects of imagined acupuncture and no touch placebo acupunctureR33AT009310 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2018 to 2021
$2.7M
Mechanistic Studies on video guided acupuncture imagery treatment of painR61AT009310 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2016 to 2017
$845k
Neural dynamics of directly and indirectly conditioned placebo/nocebo effectR21AT008707 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2016 to 2017
$479k
NCCIH NIH HHS R01 AT006364NCCIH NIH HHS R01 AT008563NCCIH NIH HHS R21 AT008707NCCIH NIH HHS R33 AT009310NCCIH NIH HHS R61 AT009310
6 · The paper itself

Abstract

backgroundBoth attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are neurodevelopmental disorders with a high prevalence. They are often comorbid and both exhibit abnormalities in sustained attention, yet common and distinct neural patterns of ASD and ADHD remain unidentified.AimsTo investigate shared and distinct functional connectivity patterns in a relatively large sample of boys (7- to 15-year-olds) with ADHD, ASD and typical development matched by age, gender and IQ.

methodWe applied machine learning techniques to investigate patterns of surface-based brain resting-state connectivity in 86 boys with ASD, 83 boys with ADHD and 125 boys with typical development.

resultsWe observed increased functional connectivity within the limbic and somatomotor networks in boys with ASD compared with boys with typical development. We also observed increased functional connectivity within the limbic, visual, default mode, somatomotor, dorsal attention, frontoparietal and ventral attention networks in boys with ADHD compared with boys with ASD. In addition, using a machine learning approach, we were able to discriminate typical development from ASD, typical development from ADHD and ASD from ADHD with accuracy rates of 76.3%, 84.1%, and 79.3%, respectively.

conclusionsOur results may shed new light on the underlying mechanisms of ASD and ADHD and facilitate the development of new diagnostic methods for these disorders.Declaration of interestJ.K. holds equity in a startup company, MNT.

Indexed as

AdolescentAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderChildFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleNerve NetNeural PathwaysDevelopmental disordersimagingneuropathology

Identifiers

PMID31088591
PMCPMC6521835
OpenAlexW2902466381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.