Evidence map›Paper›PMID 31088562›Full record

ArticleJournal of translational medicine2019

Increased risk of chronic fatigue syndrome following psoriasis: a nationwide population-based cohort study.

Shin-Yi Tsai, Hsuan-Ju Chen, Chi Chen, Chon-Fu Lio, Chien-Feng Kuo, Kam-Hang Leong, Yu-Ting Tina Wang, Tse-Yen Yang, Ching-Hui You, Wei-Sheng Wang

Open access · goldAbstract read
In one paragraph

Article in Journal of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Recent research in myalgic encephalomyelitis/chronic fatigue syndrome: an evidence map.Health technology assessment (Winchester, England) · 2025
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Psoriasis and Fibromyalgia: A Systematic Review.Journal of personalized medicine · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Shin-Yi TsaiDepartment of Laboratory Medicine, Mackay Memorial Hospital, Taipei, Taiwan. stsai22@jhu.edu.ORCID 0000-0001-7978-778X
Hsuan-Ju ChenCollege of Medicine, China Medical University, Taichung, Taiwan.
Chi ChenDepartment of Laboratory Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
Chon-Fu LioDepartment of Laboratory Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
Chien-Feng KuoInstitute of Infectious Disease, Mackay Memorial Hospital, Taipei, Taiwan.
Kam-Hang LeongDepartment of Laboratory Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
Yu-Ting Tina WangDepartment of Laboratory Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
Tse-Yen YangMolecular and Genomic Epidemiology Center, China Medical University Hospital, Taichung, Taiwan.
Ching-Hui YouNational Taiwan University, College of Medicine, Taipei, Taiwan.
Wei-Sheng WangInstitute of Infectious Disease, Mackay Memorial Hospital, Taipei, Taiwan. wvs.wang@gmail.com.ORCID 0000-0002-6760-4330
Mackay Memorial Hospital · TWChina Medical University · TWHarvard University · USJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe onset of chronic fatigue syndrome (CFS) has been shown to be associated with several immunological conditions such as infections or atopy. The aim of this study was to clarify the risk of chronic fatigue syndrome following the diagnosis of psoriasis, an immune-related dermatological disease, by analyzing the National Health Insurance Research Database of Taiwan.

method2616 patients aged 20 years or older with newly diagnosed psoriasis during 2004-2008 and 10,464 participants without psoriasis were identified. Both groups were followed up until the diagnoses of CFS were made at the end of 2011.

resultsThe relationship between psoriasis and the subsequent risk of CFS was estimated through Cox proportional hazards regression analysis, with the incidence density rates being 2.27 and 3.58 per 1000 person-years among the non-psoriasis and psoriasis populations, respectively (adjusted hazard ratio [HR] = 1.48, with 95% confidence interval [CI] 1.07-2.06). In the stratified analysis, the psoriasis group were consistently associated with a higher risk of CFS in male sex (HR = 2.05, 95% CI 1.31-3.20) and age group of ≥ 60 years old (HR = 2.32, 95% CI 1.33-4.06). In addition, we discovered that the significantly increased risk of CFS among psoriasis patients is attenuated after they receive phototherapy and/or immunomodulatory drugs.

conclusionsThe data from this population-based retrospective cohort study revealed that psoriasis is associated with an elevated risk of subsequent CFS, which is differentiated by sex and age.

Indexed as

AdultCohort StudiesComorbidityConfidence IntervalsFatigue Syndrome, ChronicFemaleHumansIncidenceMaleMiddle AgedProportional Hazards ModelsPsoriasisRisk FactorsSeverity of Illness IndexTaiwanYoung AdultChronic fatigue syndromeImmune system diseasesNational health programsPsoriasis

Identifiers

PMID31088562
PMCPMC6518753
OpenAlexW2947259193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.