Trial reportCritical care (London, England)2019
Near-infrared spectroscopy after out-of-hospital cardiac arrest.
Trial report in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02698917 (Carbon Dioxide, Oxygen and Mean Arterial Pressure After Cardiac Arrest and Resuscitation - Targeting High vs. Low Normal Values), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Carbon Dioxide, Oxygen and Mean Arterial Pressure After Cardiac Arrest and Resuscitation - Targeting High vs. Low Normal Values
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Relationship Between Cerebral Oximetry and Outcomes in Post-Cardiac Arrest Patients: A Systematic Review and Meta-Analysis.Critical care explorations · 2026Pooled it
- A randomized, double-blind trial comparing the effect of two blood pressure targets on global brain metabolism after out-of-hospital cardiac arrest.Critical care (London, England) · 2023Trial
- Bedside microdialysis for detection of early brain injury after out-of-hospital cardiac arrest.Scientific reports · 2021Trial
- Cerebral blood flow autoregulation during prehospital post-resuscitation care.Resuscitation plus · 2026Article
- Correlation of Cerebral Oxygen Saturation Change with Perioperative Complications in Elderly Patients Who Underwent Laparoscopic Partial Hepatectomy.Clinical interventions in aging · 2026Article
- Combined sonographic optic nerve sheath diameter and cerebral oximeter for predicting neurological outcome after cardiac arrest.Biomolecules & biomedicine · 2025Article
- Monitoring of perioperative tissue perfusion and impact on patient outcomes.Journal of cardiothoracic surgery · 2025Review
- Comprehensive pre- and in-hospital near-infrared-spectroscopy (NIRS) monitoring after return of spontaneous circulation predicts neurological outcome following out-of-hospital cardiac arrest: a prospective observational study and literature review.Frontiers in medicine · 2025Article
- Optimizing brain protection after cardiac arrest: advanced strategies and best practices.Interface focus · 2024Review
- Review
- Neuromonitoring after Pediatric Cardiac Arrest: Cerebral Physiology and Injury Stratification.Neurocritical care · 2024Review
- Predictive Performance of Neuron-Specific Enolase (NSE) for Survival after Resuscitation from Cardiac Arrest: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Trend of Outcome Metrics in Recent Out-of-Hospital-Cardiac-Arrest Research: A Narrative Review of Clinical Trials.Journal of clinical medicine · 2023Review
- Differences in Cerebral Oxygenation in Cardiogenic and Respiratory Cardiac Arrest Before, During, and After Cardiopulmonary Resuscitation.Journal of clinical medicine · 2023Article
- The Effects of Temperature Management on Brain Microcirculation, Oxygenation and Metabolism.Brain sciences · 2022Article
- Multimodal Neurologic Monitoring in Children With Acute Brain Injury.Pediatric neurology · 2022Review
- Monitoring and modifying brain oxygenation in patients at risk of hypoxic ischaemic brain injury after cardiac arrest.Critical care (London, England) · 2021Review
- Pre-hospital portable monitoring of cerebral regional oxygen saturation (rSOResuscitation plus · 2021Article
- European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care.Intensive care medicine · 2021Article
- Neurologic prognostication after resuscitation from cardiac arrest.Journal of the American College of Emergency Physicians open · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundCerebral hypoperfusion may aggravate neurological damage after cardiac arrest. Near-infrared spectroscopy (NIRS) provides information on cerebral oxygenation but its relevance during post-resuscitation care is undefined. We investigated whether cerebral oxygen saturation (rSO
methodsWe performed a post hoc analysis of a randomised clinical trial (COMACARE, NCT02698917) comparing two different levels of carbon dioxide, oxygen and arterial pressure after resuscitation from OHCA with ventricular fibrillation as the initial rhythm. We measured rSO
resultsThe median (inter-quartile range (IQR)) NSE concentration at 48 h was 17.5 (13.4-25.0) μg/l in patients with good neurological outcome and 35.2 (22.6-95.8) μg/l in those with poor outcome, p < 0.001. We found no significant correlation between median rSO
conclusionsWe found no association between cerebral oxygenation measured with NIRS and NSE concentrations or outcome in patients resuscitated from OHCA.
trial registrationClinicalTrials.gov, NCT02698917 . Registered on 26 January 2016.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.