ArticleJournal of orthopaedic surgery and research2019
Plasma fibrinogen may predict persistent infection before reimplantation in two-stage exchange arthroplasty for periprosthetic hip infection.
Article in Journal of orthopaedic surgery and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Reliable Diagnostic Tests and Thresholds for Preoperative Diagnosis of Non-Inflammatory Arthritis Periprosthetic Joint Infection: A Meta-analysis and Systematic Review.Orthopaedic surgery · 2022Pooled it
- Reliability of circulating fibrinogen in the diagnosis of prosthesis-related infections: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2021Pooled it
- Diagnostic accuracy of D-dimer in periprosthetic joint infection: a diagnostic meta-analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- Meta-analysis of serum and/or plasma D-dimer in the diagnosis of periprosthetic joint infection.Journal of orthopaedic surgery and research · 2020Pooled it
- Article
- Rotational Thromboelastometry as a Diagnostic Tool for Persistent Infection in Two-Stage Exchange Arthroplasty.Journal of clinical medicine · 2024Article
- Interval between two-stage exchanges: what is optimal and how do you know?Arthroplasty (London, England) · 2023Review
- The potential performance of serum albumin to globulin ratio, albumin and globulin in the diagnosis of periprosthetic joint infection and prediction of reinfection following reimplantation.BMC musculoskeletal disorders · 2022Article
- Prediction Models for Prognosis of Femoral Neck-Fracture Patients 6 Months after Total Hip Arthroplasty.International journal of general medicine · 2022Article
- Plasma levels of D-dimer and fibrin degradation product are unreliable for diagnosing periprosthetic joint infection in patients undergoing re-revision arthroplasty.Journal of orthopaedic surgery and research · 2021Article
- The change in plasma D-dimer does not help to guide the timing of reimplantation in two stage exchange for periprosthetic joint infection.Scientific reports · 2021Article
- Progress in Prevention, Diagnosis, and Treatment of Periprosthetic Joint Infection.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Combined serum biomarker analysis shows no benefit in the diagnosis of periprosthetic joint infection.International orthopaedics · 2020Article
- Current Clinical Methods for Detection of Peri-Prosthetic Joint Infection.Surgical infections · 2020Review
- Changes in serum markers failed to predict persistent infection after two-stage exchange arthroplasty.Journal of orthopaedic surgery and research · 2020Article
- Does serum interleukin-6 guide the diagnosis of persistent infection in two-stage hip revision for periprosthetic joint infection?Journal of orthopaedic surgery and research · 2019Article
- Synovial Alpha-defensin at Reimplantation in Two-stage Revision Arthroplasty to Rule Out Persistent Infection.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnosis of persistent infection before reimplantation in two-stage exchange arthroplasty for periprosthetic joint infection (PJI) remains challenging. Currently, several studies suggested coagulation-related markers, such as D-dimer and fibrinogen, may be promising in diagnose of PJI. The purpose of the study was to investigate the predictive values of plasma D-dimer and fibrinogen for assessment of persistent infection before reimplantation hip arthroplasty.
methodsWe retrospectively reviewed 129 hips that treated with two-stage exchange arthroplasty for PJI from 2012 to 2016 in our institution. The persistent infection before reimplantation was based on a modified Musculoskeletal Infection Society (MSIS) criteria. After exclusion, 102 hips were included in the final analysis. Receiver operating characteristic (ROC) curves were generated to determine the prognostic value of plasma D-dimer and fibrinogen in predicting persistent infection before reimplantation.
resultsThe area the under ROC curves (AUC) for fibrinogen (0.773; 95% confidential interval [CI], 0.569-0.905) was significantly higher than that of D-dimer (0.565; 95% CI, 0.329-0.777). With the calculated threshold of fibrinogen set at 3.61 g/L, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) was 87.5%, 62.8%, 16.7%, and 98.3%, respectively. With the threshold value of D-dimer set at 0.82 μg/mL, the sensitivity, specificity, PPV, and NPV was 83.3%, 41.9%, 21.7%, and 92.9%, respectively.
conclusionsIn conclusion, the current study reveals that the plasma fibrinogen may be a promising biomarker in predicting persistent infection before reimplantation. Further prospective studies with larger cohorts are needed to validate predictive values and optimal thresholds of coagulation-related markers.
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