Evidence map›Paper›PMID 31088460›Full record

ReviewMalaria journal2019

A case of Plasmodium malariae recurrence: recrudescence or reinfection?

Romualdo Grande, Spinello Antinori, Luca Meroni, Michela Menegon, Carlo Severini

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in Malaria journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Tropism ofEmerging microbes & infections · 2026
    Article
  2. Article
  3. Review
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  5. Article
  6. Review
  7. Article
  8. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2022
    Article
  9. ACS infectious diseases · 2021
    Article
  10. Article
  11. Article
  12. Safety and Efficacy of Tafenoquine forTherapeutics and clinical risk management · 2021
    Article
  13. Recurrence ofOpen forum infectious diseases · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Romualdo GrandeClinical Microbiology, Virology and Bioemergency, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy.
Spinello AntinoriDepartment of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy. spinello.antinori@unimi.it.ORCID http://orcid.org/0000-0003-0569-9407
Luca MeroniIII Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy.
Michela MenegonDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Carlo SeveriniDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Istituto Superiore di Sanità · ITLuigi Sacco Hospital · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlasmodium malariae is the most neglected of the six human malaria species and it is still unknown which is the mechanism underlying the long latency of this Plasmodium. CASE PRESENTATION: A case of PCR-confirmed P. malariae recurrence in a 52-year old Italian man was observed 5 months after a primary attack. In the interval between the two observed episodes of malaria the patient denied any further stay in endemic areas except for a visit to Libya, a country considered malaria-free. Genomic DNA of the P. malariae strain using five microsatellites (PM2, PM9, PM11, PM25, PM34) and the antigen marker of circumsporozoite (csp) was amplified and sequenced. Analysis of polymorphisms of the P. malariae csp central repeat region showed differences between the strains responsible of the first and second episode of malaria. A difference in the allele size was also observed for the sequence analysis of PM2 microsatellites.

conclusionsPlasmodium malariae is a challenging human malaria parasite and even with the use of molecular techniques the pathogenesis of recurrent episodes cannot be precisely explained.

Indexed as

Polymorphism, GeneticAdultAgedAntimalarialsFemaleGenome, ProtozoanHumansInfantMalariaMaleMicrosatellite RepeatsMiddle AgedPhylogenyPlasmodium malariaePolymerase Chain ReactionRecurrenceAntimalarialsLong-latencyMalariaPlasmodium malariaeRecrudescence

Identifiers

PMID31088460
PMCPMC6515619
OpenAlexW2946891620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.