ArticleBMC microbiology2019
Application of fungal fluorescent staining in oral candidiasis: diagnostic analysis of 228 specimens.
Article in BMC microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Analysis of the Uptake of Hypericin byPharmaceutics · 2026Article
- Automatic fluorescence microscopic image analyzer: a novel AI-based tool for early diagnosing superficial fungal infections.BMC infectious diseases · 2025Article
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- Innovative Biosensing Approaches for Swift Identification ofLife (Basel, Switzerland) · 2023Review
- The Utility of Metagenomic Next-Generation Sequencing (mNGS) in the Management of Patients With Bronchiectasis: A Single-Center Retrospective Study of 93 Cases.Open forum infectious diseases · 2023Article
- Applications of Laser-Induced Fluorescence in Medicine.Sensors (Basel, Switzerland) · 2022Article
- Fluorescent toys 'n' tools lighting the way in fungal research.FEMS microbiology reviews · 2021Article
- Biosensors and Diagnostics for Fungal Detection.Journal of fungi (Basel, Switzerland) · 2020Review
- Comparative evaluation of staining efficacy of calcofluor white and acridine orange in detecting fungal elements in oral potentially malignant disorders and oral squamous cell carcinoma - A retrospective study.Journal of oral and maxillofacial pathology : JOMFPArticle
- Diagnostic yield of calcofluor white in the identification of Candida albicans in oral squamous cell carcinoma.Journal of oral and maxillofacial pathology : JOMFPArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral conventional methods, including fungal culture and periodic acid-Schiff (PAS) reagent staining, have been used to diagnose oral candidiasis. The aim of this study was to evaluate the efficacy of a novel method, fungal fluorescent staining, in relation to conventional protocols in the diagnosis of oral candidiasis.
methodsWe collected 106 oral swabs and 122 oral biopsy tissues from patients highly suspected with oral candidiasis. We applied fungal culture and periodic acid-Schiff reagent staining as the gold standard diagnostic tools. The efficacy of these methods in determining the presence of Candida was compared with that of fluorescent staining.
resultsIn the majority of specimens subjected to fluorescent staining, fungal organisms were distinguished by blue fluorescence surrounding their tubular or annular shapes. The sensitivity, specificity, Youden index, positive predictive value and negative predictive value of the fluorescent staining method were 82.7, 93.5, 76.7, 96.8 and 69.1% in oral swabs and 90.0, 92.9, 82.9, 96.0 and 82.9% in oral biopsy tissues, respectively.
conclusionsFungal fluorescent staining represents a rapid method for detection of Candida, supporting its potential utility as an effective early diagnostic tool for oral candidiasis.
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