Evidence map›Paper›PMID 31088291›Full record

ArticleAntioxidants & redox signaling2019

Energetic Dysfunction Is Mediated by Mitochondrial Reactive Oxygen Species and Precedes Structural Remodeling in Metabolic Heart Disease.

Ivan Luptak, Fuzhong Qin, Aaron L Sverdlov, David R Pimentel, Marcello Panagia, Dominique Croteau, Deborah A Siwik, Markus M Bachschmid, Huamei He, James A Balschi and 1 more

Open access · greenAbstract read
In one paragraph

Article in Antioxidants & redox signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  7. Aging and sex differences in salt sensitivity of blood pressure.Clinical science (London, England : 1979) · 2025
    Review
  8. Review
  9. Review
  10. Sex-based differences in short- and longer-term diet-induced metabolic heart disease.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Mitochondrial Dysfunction in the Cardio-Renal Axis.International journal of molecular sciences · 2023
    Review
  15. Review
  16. Review
  17. Synthesis, characterization and antitumor mechanism investigation of ruthenium(II) polypyridyl complexes with artesunate moiety.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021
    Article
  18. A Retinoic Acid ReceptorThe Journal of pharmacology and experimental therapeutics · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Ivan Luptak1Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts.
Fuzhong Qin1Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts.
Aaron L Sverdlov1Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts.
David R Pimentel1Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts.
Marcello Panagia1Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts.
Dominique Croteau1Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts.
Deborah A Siwik1Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts.
Markus M Bachschmid3Vascular Biology Unit, Boston University School of Medicine, Boston, Massachusetts.
Huamei He4Physiological NMR Core Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
James A Balschi4Physiological NMR Core Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Wilson S Colucci1Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts.
Boston University · USBrigham and Women's Hospital · US

Funding

Redox Control of Hepatic Lipid MetabolismR01DK103750 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BACHSCHMID, MARKUS MICHAEL · 2015 to 2019
$1.8M
Multiplexed Imaging of Energy Metabolism in Murine Models of Heart FailureK08HL123744 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI PANAGIA, MARCELLO · 2014 to 2018
$767k
NHLBI NIH HHS K08 HL123744NIDDK NIH HHS R01 DK103750
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Energy MetabolismAdenosine TriphosphateAnimalsBiomarkersDisease SusceptibilityEchocardiographyFibrosisHeart DiseasesHydrogen PeroxideImmunohistochemistryMetabolic DiseasesMiceMitochondria, HeartMyocardial ContractionMyocardiumReactive Oxygen SpeciesAdenosine TriphosphateBiomarkersHydrogen PeroxideReactive Oxygen Speciescatalasecontractile functionmetabolic syndromemetabolismmitochondriaobesityROS

Identifiers

PMID31088291
PMCPMC6648235
OpenAlexW2946523286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.