Evidence map›Paper›PMID 31088072›Full record

ArticleChemical research in toxicology2019

Hydrolyzable Tannins Are Iron Chelators That Inhibit DNA Repair Enzyme ALKBH2.

Fangyi Chen, Qi Tang, Hang Ma, Ke Bian, Navindra P Seeram, Deyu Li

Open access · greenAbstract read
In one paragraph

Article in Chemical research in toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Genome-Protecting Compounds as Potential Geroprotectors.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fangyi ChenDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy , University of Rhode Island , Kingston , Rhode Island 02881 , United States.
Qi TangDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy , University of Rhode Island , Kingston , Rhode Island 02881 , United States.
Hang MaDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy , University of Rhode Island , Kingston , Rhode Island 02881 , United States.ORCID 0000-0001-7565-6889
Ke BianDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy , University of Rhode Island , Kingston , Rhode Island 02881 , United States.ORCID 0000-0002-1268-2382
Navindra P SeeramDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy , University of Rhode Island , Kingston , Rhode Island 02881 , United States.ORCID 0000-0001-7064-2904
Deyu LiDepartment of Biomedical and Pharmaceutical Sciences, College of Pharmacy , University of Rhode Island , Kingston , Rhode Island 02881 , United States.ORCID 0000-0002-1082-0569
University of Rhode Island · US

Funding

Training CoreP20GM103430 · NIGMS · UNIVERSITY OF RHODE ISLAND · PI Bongsup P Cho · 2012 to 2026
$63.6M
Mutational spectra of bulky DNA lesionsR01ES028865 · NIEHS · UNIVERSITY OF RHODE ISLAND · PI LI, DEYU · 2018 to 2022
$2.1M
Inhibitory Effect of Nitric Oxide on DNA Repair EnzymesR15CA213042 · NCI · UNIVERSITY OF RHODE ISLAND · PI LI, DEYU · 2017 to 2017
$411k
NCI NIH HHS R15 CA213042NIEHS NIH HHS R01 ES028865NIGMS NIH HHS P20 GM103430
6 · The paper itself

Abstract

Hydrolyzable tannins are a class of polyphenolic compounds commonly found in natural products. In this work, we studied the in vitro inhibitory mechanism of six molecules in this class on ALKBH2, an Fe(II)/α-ketoglutarate-dependent DNA repair enzyme in the AlkB family. We determined the IC

Indexed as

DNA RepairAlkB Homolog 2, Alpha-Ketoglutarate-Dependent DioxygenaseDose-Response Relationship, DrugEnzyme InhibitorsHumansHydrolyzable TanninsIron Chelating AgentsMolecular StructureStructure-Activity RelationshipALKBH2 protein, humanAlkB Homolog 2, Alpha-Ketoglutarate-Dependent DioxygenaseEnzyme InhibitorsHydrolyzable TanninsIron Chelating Agents

Identifiers

PMID31088072
PMCPMC6890495
OpenAlexW2945796691

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.