ArticleObesity (Silver Spring, Md.)2019
Effects of GABA and Leptin Receptor-Expressing Neurons in the Lateral Hypothalamus on Feeding, Locomotion, and Thermogenesis.
Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- The hindbrain-hypothalamic noradrenergic pathway controls homeostatic food intake but not cue-induced appetitive behaviors.Journal of neuroendocrinology · 2026Article
- Balancing acts: lateral hypothalamic circuits coordinating feeding, anxiety, and social interactions.Reviews in endocrine & metabolic disorders · 2026Review
- From identity to function: unveiling the cellular complexity of hypothalamic feeding circuits.Reviews in endocrine & metabolic disorders · 2026Review
- A lateral hypothalamic neuronal population expressing leptin receptors counteracts anxiety to enable adaptive behavioral responses.Nature neuroscience · 2025Article
- Direct interoceptive input to the insular cortex shapes learned feeding behavior.bioRxiv : the preprint server for biology · 2025Article
- Lateral hypothalamus and eating: cell types, molecular identity, anatomy, temporal dynamics and functional roles.Experimental & molecular medicine · 2025Review
- A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis.Nature metabolism · 2024Article
- Synergistic effects of peripheral GABA and GABA-transaminase inhibitory drugs on food intake control and weight loss in high-fat diet-induced obese mice.Frontiers in pharmacology · 2024Article
- High Gamma-Aminobutyric Acid (GABA) Oolong Tea Alleviates High-Fat Diet-Induced Metabolic Disorders in Mice.ACS omega · 2023Article
- Control of energy homeostasis by the lateral hypothalamic area.Trends in neurosciences · 2023Review
- Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA.Nature metabolism · 2023Article
- Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice.Nature communications · 2023Article
- Complementary lateral hypothalamic populations resist hunger pressure to balance nutritional and social needs.Cell metabolism · 2023Article
- Neurohormonal Changes in the Gut-Brain Axis and Underlying Neuroendocrine Mechanisms following Bariatric Surgery.International journal of molecular sciences · 2022Review
- Novel pituitary actions of GnRH in teleost: The link between reproduction and feeding regulation.Frontiers in endocrinology · 2022Article
- Lateral hypothalamic LEPR neurons drive appetitive but not consummatory behaviors.Cell reports · 2021Article
- Optimization of whole-brain rabies virus tracing technology for small cell populations.Scientific reports · 2021Article
- LRP1 regulates food intake and energy balance in GABAergic neurons independently of leptin action.American journal of physiology. Endocrinology and metabolism · 2021Article
- Neurotensin in reward processes.Neuropharmacology · 2020Review
- GABAergic function in the lateral hypothalamus regulates feeding behavior: Possible mediation via orexin.Neuropsychopharmacology reports · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe lateral hypothalamus (LH) is known for its role in feeding, and it also regulates other aspects of energy homeostasis. How genetically defined LH neuronal subpopulations mediate LH effects on energy homeostasis remains poorly understood. The behavioral effects of chemogenetically activating LH gamma-aminobutyric acid (GABA) and the more selective population of LH GABA neurons that coexpress the leptin receptor (LepR) were compared.
methodsLepR-cre and VGAT-cre mice were injected with AAV5-hSyn-DIO-hM3DGq-mCherry in the LH. The behavioral effects of LH GABA or LH LepR neuronal activation on feeding, locomotion, thermogenesis, and body weight were assessed.
resultsThe activation of LH GABA neurons increased body temperature (P ≤ 0.008) and decreased body weight (P ≤ 0.01) despite decreased locomotor activity (P = 0.03) and transiently increased chow intake (P ≤ 0.009). Also, similar to other studies, this study found that activation of LH GABA neurons induced gnawing on both food and nonfood (P = 0.001) items. Activation of LH LepR neurons decreased body weight (P ≤ 0.01) and chow intake when presented on the cage floor (P ≤ 0.04) but not when presented in the cage top and increased locomotor activity (P = 0.002) and body temperature (P = 0.03).
conclusionsLH LepR neurons are a subset of LH GABA neurons, and LH LepR activation more specifically regulates energy homeostasis to promote a negative energy balance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.