Evidence map›Paper›PMID 31087702›Full record

ArticleJournal of leukocyte biology2019

Loss of monocyte metabolic plasticity in endotoxin tolerance: A model for understanding sepsis-induced immune paralysis?

David L Williams, Chuanfu Li, Edward R Sherwood

Abstract readEditorialComment
In one paragraph

Article in Journal of leukocyte biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Metabolic substrate utilization in stress-induced immune cells.Intensive care medicine experimental · 2020
    Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

David L WilliamsDepartment of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, USA.
Chuanfu LiDepartment of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, USA.
Edward R SherwoodCenter of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, Johnson City, Tennessee, 37614, USA.

Funding

Role of Toll-Like Receptor Signaling in Cardiac IschemiaR01HL071837 · NHLBI · EAST TENNESSEE STATE UNIVERSITY · PI LI, CHUANFU · 2003 to 2022
$6.1M
Training Innate Immunity: A new approach to the treatment of SepsisR01GM119197 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI SHERWOOD, EDWARD R, WILLIAMS, DAVID L. · 2016 to 2024
$4.6M
Innate Immunity and Cardiovascular Function in SepsisR01GM083016 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI LI, CHUANFU, WILLIAMS, DAVID L. · 2009 to 2021
$3.8M
NHLBI NIH HHS R01 HL071837NIGMS NIH HHS R01 GM083016NIGMS NIH HHS R01 GM119197
6 · The paper itself

Abstract

Discussion on implications of the immune paralysis that occurs in many sepsis patients.

Indexed as

MonocytesSepsisEndotoxinsHumansImmune ToleranceRespiratory BurstEndotoxins

Identifiers

PMID31087702
PMCPMC6597287

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.