Evidence map›Paper›PMID 31087647›Full record

Observational studyInternational journal of cancer2020

Fine-mapping of a novel premenopausal breast cancer susceptibility locus at Chr4q31.22 in Caucasian women and validation in African and Chinese women.

Mahalakshmi Kumaran, Sunita Ghosh, Anil A Joy, John R Mackey, Carol E Cass, Wei Zheng, Yutaka Yasui, Sambasivarao Damaraju

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Observational
  2. Article
  3. Immune Response-Related Genes -Pharmacogenomics and personalized medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Mahalakshmi KumaranDepartment of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.
Sunita GhoshDepartment of Oncology, University of Alberta, Edmonton, AB, Canada.
Anil A JoyDepartment of Oncology, University of Alberta, Edmonton, AB, Canada.
John R MackeyDepartment of Oncology, University of Alberta, Edmonton, AB, Canada.
Carol E CassDepartment of Oncology, University of Alberta, Edmonton, AB, Canada.
Wei ZhengDepartment of Medicine, Vanderbilt University, Nashville, TN.
Yutaka YasuiDepartment of Epidemiology & Cancer Control, St. Jude Children's Research Hospital, Memphis, TN.
Sambasivarao DamarajuDepartment of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0002-7440-1195
University of Alberta · CAAlberta Health Services · CASt. Jude Children's Research Hospital · USVanderbilt University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously identified a novel breast cancer susceptibility variant on chromosome 4q31.22 locus (rs1429142) conferring risk among women of European ancestry. Here, we report replication of findings, validation of the variant in diverse populations and fine-mapping of the associated locus in Caucasian population. The SNP rs1429142 (C/T, minor allele frequency 18%) showed association for the overall breast cancer risk in Stages 1-4 (n = 4,331 cases/4271 controls; p = 4.35 × 10

Indexed as

Genetic Predisposition to DiseasePremenopauseAdultAgedAged, 80 and overAge DistributionAlbertaAsian PeopleBlack PeopleBreast NeoplasmsCase-Control StudiesChromosome MappingChromosomes, Human, Pair 4Datasets as TopicEnhancer Elements, GeneticFemalebreast cancerfine-mappinggenome-wide association studiesmenopausal statussusceptibility variants

Identifiers

PMID31087647
PMCPMC7004017
OpenAlexW2945049032

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.