ArticleAmerican journal of human biology : the official journal of the Human Biology Council2019
Scaling of adult human bone and skeletal muscle mass to height in the US population.
Article in American journal of human biology : the official journal of the Human Biology Council, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
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- Higher circulating FGF21, lower protein intake, and lower muscle mass: Associations with a higher risk of mortality.Journal of internal medicine · 2025Article
- Assessing the Potential of Hand Grip Strength as an Indicator of Spinal Muscle Size.Sports medicine international open · 2025Article
- The relationship between cardiorespiratory fitness and indices of fat mass and fat-free mass in adults.Frontiers in sports and active living · 2025Article
- Weight/heightObesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Sarcopenia Identification Using Alternative Vertebral Landmarks in Individuals with Lung Cancer.Muscles (Basel, Switzerland) · 2024Article
- What could be the reasons for not losing weight even after following a weight loss program?Journal of health, population, and nutrition · 2024Review
- Clinical, functional, and opportunistic CT metrics of sarcopenia at the point of imaging care: analysis of all-cause mortality.Skeletal radiology · 2024Article
- DJournal of cachexia, sarcopenia and muscle · 2022Review
- Phenotypic differences between people varying in muscularity.Journal of cachexia, sarcopenia and muscle · 2022Article
- Scaling of computed tomography body composition to height: relevance of height-normalized indices in patients with colorectal cancer.Journal of cachexia, sarcopenia and muscle · 2022Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesThe scaling of structural components to body size is well studied in mammals, although comparable human observations in a large and diverse sample are lacking. The current study aimed to fill this gap by examining the scaling relationships between total body (TB) and regional bone and skeletal muscle (SM) mass with body size, as defined by stature, in a nationally representative sample of the US population.
methodsSubjects were 17,126 non-Hispanic (NH) white, NH black, and Mexican American men and women, aged ≥18 years, evaluated in the National Health and Nutrition Examination Survey who had TB and regional bone mineral (BMin) and lean soft tissue (LST) mass measured by dual-energy X-ray absorptiometry. BMin and appendicular LST served as surrogate bone and SM mass measures, respectively. The allometric model, BMin or LST = α(height)
resultsThe findings were similar across all gender and race groups: body mass scaled to height with powers of ~2.0 (mean β ± SE, 1.94 ± 0.08-2.29 ± 0.09) while TB and appendicular BMin and appendicular LST scaled to height with consistently larger powers than those for body mass (eg, all P < .05 in NH white men and women); the largest BMin and LST scaling powers to height were observed in the lower extremities.
conclusionsBone and SM mass, notably those of the lower extremities, increase as proportions of body mass with greater adult height. Metabolic and biomechanical implications emerge from these observations, the first of their kind in a representative adult US population sample.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.