Evidence map›Paper›PMID 31087541›Full record

ArticlePhysiological reports2019

Differential MicroRNA expression following head-down tilt bed rest: implications for cardiovascular responses to microgravity.

Carl J Ade, Debra A Bemben

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Circulating MiR-21 expression is upregulated after 30 days of head-down tilt bed rest.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Carl J AdeDepartment of Kinesiology, Kansas State University, Manhattan, Kansas.
Debra A BembenDepartment of Health and Exercise Science, University of Oklahoma, Norman, Oklahoma.
Kansas State University · USUniversity of Oklahoma · US

Funding

NASA NNX16AR26G
6 · The paper itself

Abstract

Head-down tilt bedrest (HDBR), an analog of spaceflight, elicits changes in cardiovascular function that adversely affect astronaut performance. It is therefore fundamental to elucidate the molecular regulators of these changes. Study aim was to determine if cardiovascular-related circulating microRNA (miRNA) are altered following HDBR and if they relate to changes in cardiac function and peak aerobic capacity. Eleven participants completed 30-days HDBR at an ambient CO

Indexed as

Weightlessness SimulationAdultBed RestCardiac OutputCardiovascular Physiological PhenomenaExercise ToleranceFemaleGene Expression RegulationHead-Down TiltHumansMaleMicroRNAsMiddle AgedOxygen ConsumptionSpace FlightUp-RegulationMicroRNAsBed restcardiovascularcirculating microRNAc-miRNAmicrogravityMicroRNA

Identifiers

PMID31087541
PMCPMC6513770
OpenAlexW2946248103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.