Evidence map›Paper›PMID 31087539›Full record

ArticlePhysiological reports2019

Impaired SIRT1 activity leads to diminution in glomerular endowment without accelerating age-associated GFR decline.

Ashley R Bellin, Yanling Zhang, Kerri Thai, Norman D Rosenblum, Luise A Cullen-McEwen, John F Bertram, Richard E Gilbert

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Ashley R BellinKeenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Yanling ZhangKeenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Kerri ThaiKeenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Norman D RosenblumHospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Luise A Cullen-McEwenDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute, and Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
John F BertramDevelopment and Stem Cells Program, Monash Biomedicine Discovery Institute, and Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia.
Richard E GilbertKeenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
St. Michael's Hospital · CADiscovery Institute · USHospital for Sick Children · CA

Funding

CIHR FRN119368
6 · The paper itself

Abstract

Glomerular filtration rate (GFR) declines with age such that the prevalence of chronic kidney disease is much higher in the elderly. SIRT1 is the leading member of the sirtuin family of NAD

Indexed as

AgingAnimalsBody WeightDisease Models, AnimalGlomerular Filtration RateHistone DeacetylasesKidneyKidney GlomerulusMaleMice, Mutant StrainsNephronsOrgan SizePoint MutationSirtuin 1Histone DeacetylasesSirt1 protein, mouseSirtuin 1Agingglomerular endowmentglomerular filtration rateSIRT1

Identifiers

PMID31087539
PMCPMC6513772
OpenAlexW2946339731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.