Evidence map›Paper›PMID 31087499›Full record

ArticleMolecular nutrition & food research2019

Brain Trauma Disrupts Hepatic Lipid Metabolism: Blame It on Fructose?

Shraddha D Rege, Luiz Royes, Brandon Tsai, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. The Renin Angiotensin System as a Therapeutic Target in Traumatic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  8. Article
  9. Article
  10. The interaction between brain and liver regulates lipid metabolism in the TBI pathology.Biochimica et biophysica acta. Molecular basis of disease · 2021
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Shraddha D RegeDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Luiz RoyesDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Brandon TsaiDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Guanglin ZhangDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Xia YangDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Fernando Gomez-PinillaDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0001-5869-2204
University of California, Los Angeles · US

Funding

Restoration of Homeostasis After Brain TraumaR01NS050465 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOMEZ-PINILLA, FERNANDO · 2005 to 2019
$5.5M
DHA Reverses Gene Network Signatures of Fructose-induced Metabolic SyndromeR01DK104363 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YANG, XIA · 2015 to 2019
$2.4M
NIDDK NIH HHS R01 DK104363NINDS NIH HHS R01 NS050465
6 · The paper itself

Abstract

scopeThe action of brain disorders on peripheral metabolism is poorly understood. The impact of traumatic brain injury (TBI) on peripheral organ function and how TBI effects can be influenced by the metabolic perturbation elicited by fructose ingestion are studied. METHODS AND

resultsIt is found that TBI affects glucose metabolism and signaling proteins for insulin and growth hormone in the liver; these effects are exacerbated by fructose ingestion. Fructose, principally metabolized in the liver, potentiates the action of TBI on hepatic lipid droplet accumulation. Studies in isolated cultured hepatocytes identify GH and fructose as factors for the synthesis of lipids. The liver has a major role in the synthesis of lipids used for brain function and repair. TBI results in differentially expressed genes in the hypothalamus, primarily associated with lipid metabolism, providing cues to understand central control of peripheral alterations. Fructose-fed TBI animals have elevated levels of markers of inflammation, lipid peroxidation, and cell energy metabolism, suggesting the pro-inflammatory impact of TBI and fructose in the liver.

conclusionResults reveal the impact of TBI on systemic metabolism and the aggravating action of fructose. The hypothalamic-pituitary-growth axis seems to play a major role in the regulation of the peripheral TBI pathology.

Indexed as

Lipid MetabolismAnimalsBody WeightBrain Injuries, TraumaticCells, CulturedEatingEnergy MetabolismFructoseGlucoseHepatitisHepatocytesHypothalamusInsulin-Like Growth Factor ILiverMaleMiceFructoseGlucoseinsulin-like growth factor-1, ratInsulin-Like Growth Factor Ifructosegrowth hormoneinsulin signalinglipidstraumatic brain injuries

Identifiers

PMID31087499
PMCPMC6763319
OpenAlexW2946078762

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.