ArticleAngewandte Chemie (International ed. in English)2019
Cobalt-Catalyzed Aminocarbonylation of Alkyl Tosylates: Stereospecific Synthesis of Amides.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 41 citations in OpenAlex.
- Control of axial stereochemistry for the enantioselective construction of a QUINAP library.Chemical science · 2026Article
- Cobalt-Catalyzed Syntheses of Acrylamides and Succindiamides from Alkynes and Amines Promoted by Light.Journal of the American Chemical Society · 2026Article
- Pincer-cobalt boosts divergent alkene carbonylation under tandem electro-thermo-catalysis.Nature communications · 2025Article
- Palladium-Catalyzed Carbonylative Fluoroalkylation of 1,3-Enynes to Access Allenyl Primary Amides.Organic letters · 2025Article
- Iron-Catalyzed Carbonylation Reactions with Carbon Monoxide.Angewandte Chemie (International ed. in English) · 2025Review
- Total Synthesis of the Sex Pheromone ofInternational journal of molecular sciences · 2024Article
- Palladium-Catalyzed Carbonylations: Application in Complex Natural Product Total Synthesis and Recent Developments.The Journal of organic chemistry · 2023Review
- Cobalt-Catalyzed Deaminative Amino- and Alkoxycarbonylation of Aryl Trialkylammonium Salts Promoted by Visible Light.Angewandte Chemie (International ed. in English) · 2022Article
- Stereospecific Nickel-Catalyzed Reductive Cross-Coupling of Alkyl Tosylate and Allyl Alcohol Electrophiles.Organic letters · 2021Article
- Cobalt catalysed aminocarbonylation of thiols in batch and flow for the preparation of amides.RSC advances · 2021Article
- Cobalt-catalyzed aminocarbonylation of (hetero)aryl halides promoted by visible light.Chemical science · 2020Article
- Manganese-Catalyzed Stereospecific Hydroxymethylation of Alkyl Tosylates.Organic letters · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Metal-catalyzed aminocarbonylation is a standard approach for installing amide functionality in chemical synthesis. Despite broad application of this transformation using aryl or vinyl electrophiles, there are few examples involving unactivated aliphatic substrates. Furthermore, there are no stereocontrolled aminocarbonylations of alkyl electrophiles known. Herein, we report a stereospecific aminocarbonylation of unactivated alkyl tosylates for the synthesis of enantioenriched amides. This cobalt-catalyzed transformation uses a remarkably broad range of amines and proceeds with excellent stereospecificity and chemoselectivity.
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