Trial reportJournal of viral hepatitis2019
Persistence of HBsAg-specific antibodies and immune memory two to three decades after hepatitis B vaccination in adults.
Trial report in Journal of viral hepatitis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02901951 (Long-term Persistence of Immunity to Hepatitis B in Adults Vaccinated 20 to 30 Years Ago With Engerix-B), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long-term Persistence of Immunity to Hepatitis B in Adults Vaccinated 20 to 30 Years Ago With Engerix-B
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- A systematic review reveals that African children of 15-17 years demonstrate low hepatitis B vaccine seroprotection rates.Scientific reports · 2023Pooled it
- Safety and Immunogenicity of 1 or 2 Additional Doses of the Adjuvanted Recombinant Zoster Vaccine Administered 5-6 Years After Primary Vaccination in Adults ≥50 Years.Open forum infectious diseases · 2026Trial
- Human papillomavirus (HPV) vaccines in adults: Learnings from long-term follow-up of quadrivalent HPV vaccine clinical trials.Human vaccines & immunotherapeutics · 2023Trial
- One- and Two-Dose Vaccinations With Modified Vaccinia Ankara-Bavarian Nordic Induce Durable B-Cell Memory Responses Comparable to Replicating Smallpox Vaccines.The Journal of infectious diseases · 2023Trial
- Persistence of HBsAg-specific antibodies and immune memory two to three decades after hepatitis B vaccination in adults.Journal of viral hepatitis · 2019Trial
- Serological evidence of hepatitis B virus exposure and vaccination coverage trends in health sciences students in Albania.World journal of virology · 2026Article
- Hepatitis B Vaccine Response in Children of Vaccinated Versus Unvaccinated Mothers: A Retrospective Cohort Study.Journal of viral hepatitis · 2026Article
- Factors Associated with the Anamnestic Immune Response Following Hepatitis B Booster Vaccination in the Elderly.Vaccines · 2026Article
- MZB1 expression levels are associated with long-term maintenance of high anti-HBs titers: single-cell RNA-seq with validation by nested case-control and intervention studies.Frontiers in immunology · 2026Article
- Review
- From Hyperendemic to Low Endemicity: The Effect of Hepatitis B Vaccination on HBV and HDV Prevalence in the Brazilian Amazon.Pathogens (Basel, Switzerland) · 2025Article
- Dynamics of HBsAb persistence and associated BCR IgG-H CDR3 repertoire features in ultra-high versus extremely low responders to HBV vaccination.Frontiers in immunology · 2025Article
- How does geographical diversity shape vaccine efficacy?Clinical and experimental vaccine research · 2024Review
- Hepatitis B virus in oocytes and embryos: pregnancy outcomes and children's health.F&S reports · 2024Article
- The Impact of Smoking on Long-Term Protection Following Hepatitis B Vaccination: A 24-Year Cohort Study.Viruses · 2024Article
- Overview of Hepatitis B Vaccine Non-Response and Associated B Cell Amnesia: A Scoping Review.Pathogens (Basel, Switzerland) · 2024Article
- Hepatitis B Vaccine: Four Decades on.Vaccines · 2024Review
- Effectiveness of Hepatitis B Vaccination for Patients With Inflammatory Bowel and Celiac Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023Article
- Seroprotection of Hepatitis B Vaccine in Dental Students Two Decades after Infant Immunization and the Possible Need for Revaccination.European journal of dentistry · 2023Article
- Durability of Cellular and Humoral Immunity After Primary and Booster Hepatitis B Vaccination of Individuals Living With Perinatally Acquired HIV.Open forum infectious diseases · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The duration of protection after hepatitis B vaccination is not exactly known. This phase IV study evaluated antibody persistence and immune memory 20-30 years after adult immunization with recombinant hepatitis B vaccine (HBsAg vaccine, Engerix-B) in routine clinical practice. Men and women 40-60 years old, with documented evidence of vaccination with three or four HBsAg vaccine doses 20-30 years earlier and without subsequent booster, were enrolled and received HBsAg vaccine as challenge dose. HBsAg-specific antibodies (anti-HBs) and frequencies of HBsAg-specific circulating memory B cells and CD4
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.