Evidence map›Paper›PMID 31087266›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021

Focal reduction in left ventricular

Letizia Spinelli, Massimo Imbriaco, Giuseppe Giugliano, Carmela Nappi, Valeria Gaudieri, Eleonora Riccio, Antonio Pisani, Bruno Trimarco, Alberto Cuocolo

Abstract read
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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Detection of sympathetic denervation defects in Fabry disease by hybrid [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  5. Impairment of sympathetic activity in Fabry disease cardiomyopathy: A further challenge for cardiac imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  6. Multimodality imaging approach to Fabry cardiomyopathy: Any role for nuclear cardiology?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Review
  7. Review
  8. Review
  9. Anderson-Fabry disease: Worthy to in-SPECT the nerves?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Letizia SpinelliDepartment of Advanced Biomedical Sciences, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy. letspine@unina.it.
Massimo ImbriacoDepartment of Advanced Biomedical Sciences, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy.
Giuseppe GiuglianoDepartment of Advanced Biomedical Sciences, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy.
Carmela NappiDepartment of Advanced Biomedical Sciences, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy.
Valeria GaudieriDepartment of Advanced Biomedical Sciences, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy.
Eleonora RiccioDepartment of Public Health, Nephrology Unit, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy.
Antonio PisaniDepartment of Public Health, Nephrology Unit, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy.
Bruno TrimarcoDepartment of Advanced Biomedical Sciences, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy.
Alberto CuocoloDepartment of Advanced Biomedical Sciences, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy.
University of Naples Federico II · ITFederico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAbnormalities of cardiac sympathetic innervation have been demonstrated in Anderson-Fabry disease (AFD). We aimed to investigate the relationship between regional left ventricular (LV) denervation and regional function abnormalities.

methodsTwenty-four AFD patients (43.7 ± 12.8 years) were studied by

resultsSegmental longitudinal strain worsened as MIBG uptake score increased (P < 0.001). By ROC analysis, a segmental longitudinal strain > - 16.2% predicted a segmental MIBG uptake score ≥1, with 79.7% sensitivity and 65.3% specificity. Segmental MIBG uptake defects were found in 13 out 24 AFD patients. LV mass index (60.8 ± 10.1 vs. 41.4 ± 9.8 g/h

conclusionsReduced cardiac MIBG uptake reflects the severity of cardiac involvement in AFD patients. LV longitudinal function impairment seems to be an earlier disease feature than regional myocardial denervation.

Indexed as

3-IodobenzylguanidineAdultFabry DiseaseFemaleHeart VentriclesHumansMaleMiddle AgedRadiopharmaceuticalsSympathetic Nervous SystemSystoleTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftYoung Adult3-IodobenzylguanidineRadiopharmaceuticalsCardiac innervationCardiomyopathyEchoSPECT

Identifiers

PMID31087266
OpenAlexW2946444171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.