ArticleMetabolomics : Official journal of the Metabolomic Society2019
Comparative metabolome-based classification of Senna drugs: a prospect for phyto-equivalency of its different commercial products.
Article in Metabolomics : Official journal of the Metabolomic Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Traditional Uses, Phytochemistry, and Multi-Target Pharmacological Activities of Senna alexandrina.Chemistry & biodiversity · 2026Review
- Untargeted Metabolomics for Profiling of Cascara, Senna, Rhubarb, and Frangula Metabolites.Metabolites · 2025Article
- Comparative LC-ESIMS-Based Metabolite Profiling ofMetabolites · 2023Article
- Effect of Maturity Stage on Cereal and Leguminous Seeds' Metabolome as Analyzed Using Gas Chromatography Mass-Spectrometry (GC-MS) and Chemometric Tools.Metabolites · 2023Article
- Emerging applications of metabolomics in food science and future trends.Food chemistry: X · 2022Article
- Profiling of Primary Metabolites and Volatiles in Apricot (Foods (Basel, Switzerland) · 2022Article
- Structural Elucidation of an Atropisomeric Entcassiflavan-(4β→8)-Epicatechin Isolated fromMolecules (Basel, Switzerland) · 2022Article
- Nutrient and Sensory Metabolites Profiling ofMolecules (Basel, Switzerland) · 2020Article
- NMR-Based Plant Metabolomics in Nutraceutical Research: An Overview.Molecules (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe demand to develop efficient and reliable analytical methods for the quality control of nutraceuticals is on the rise, together with an increase in the legal requirements for safe and consistent levels of its active principles.
objectiveTo establish a reliable model for the quality control of widely used Senna preparations used as laxatives and assess its phyto-equivalency.
methodsA comparative metabolomics approach via NMR and MS analyses was employed for the comprehensive measurement of metabolites and analyzed using chemometrics.
resultsUnder optimized conditions, 30 metabolites were simultaneously identified and quantified including anthraquinones, bianthrones, acetophenones, flavonoid conjugates, naphthalenes, phenolics, and fatty acids. Principal component analysis (PCA) was used to define relative metabolite differences among Senna preparations. Furthermore, quantitative
conclusionThis study provides the first comparative metabolomics approach utilizing NMR and UPLC-MS to reveal for secondary metabolite compositional differences in Senna preparations that could readily be applied as a reliable quality control model for its analysis.
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