ArticlemSystems
Pseudomonas aeruginosa Alters Its Transcriptome Related to Carbon Metabolism and Virulence as a Possible Survival Strategy in Blood from Trauma Patients.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Molecular exploration of host-pathogen interactions in severeFrontiers in medicine · 2025Pooled it
- Pan-Genomic and Phenotypic Characterisation of Petroleum Hydrocarbon Degradation by Pseudomonas Species.Environmental microbiology reports · 2026Review
- Host niche-specific challenges hindering the treatment of polymicrobial infections.Journal of bacteriology · 2025Review
- Identification of the Pseudomonas aeruginosa AgtR-CspC-RsaL pathway that controls Las quorum sensing in response to metabolic perturbation and Staphylococcus aureus.PLoS pathogens · 2025Article
- Malonate is relevant to the lung environment and induces genome-wide stress responses in Pseudomonas aeruginosa.Research square · 2024Article
- Decoding Genetic Features and Antimicrobial Susceptibility ofInternational journal of molecular sciences · 2022Article
- The Impact of Chromate onFrontiers in microbiology · 2022Article
- Transcriptional Profiling of Pseudomonas aeruginosa Infections.Advances in experimental medicine and biology · 2022Review
- Malonate utilization by Pseudomonas aeruginosa affects quorum-sensing and virulence and leads to formation of mineralized biofilm-like structures.Molecular microbiology · 2021Article
- Prevalence of the Genes Associated with Biofilm and Toxins Synthesis amongst theAntibiotics (Basel, Switzerland) · 2021Article
- The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection.Nature communications · 2021Article
- VasH Contributes to Virulence ofFrontiers in veterinary science · 2021Article
- Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2020Article
- New markers for sepsis caused by Pseudomonas aeruginosa during burn infection.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Volatilomes of Bacterial Infections in Humans.Frontiers in neuroscience · 2020Review
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trauma patients (TPs) are highly susceptible to infections, which often lead to sepsis. Among the numerous causative agents, Pseudomonas aeruginosa is especially important, as P. aeruginosa sepsis is often fatal. Understanding the mechanism of its pathogenesis in bloodstream infections is imperative; however, this mechanism has not been previously described. To examine the effect of trauma-induced changes in blood on the expression of P. aeruginosa genes, we grew strain UCBPP-PA14 (PA14) in blood samples from eight TPs and seven healthy volunteers (HVs). Compared with its growth in blood from HVs, the growth of PA14 in blood from TPs significantly altered the expression of 285 genes. Genes whose expression was significantly increased were related to carbon metabolism, especially malonate utilization and mannitol uptake, and efflux of heavy metals. Genes whose expression was significantly reduced included genes of the type VI secretion system, genes related to uptake and metabolism of amino acids, and genes related to biosynthesis and transport of the siderophores pyoverdine and pyochelin. These results suggest that during systemic infection in trauma patients, and to adapt to the trauma-induced changes in blood, P. aeruginosa adjusts positively and negatively the expression of numerous genes related to carbon metabolism and virulence, respectively.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.