Evidence map›Paper›PMID 31086827›Full record

ArticleNeurology. Genetics2019

HTT haplogroups in Finnish patients with Huntington disease.

Susanna Ylönen, Jussi O T Sipilä, Marja Hietala, Kari Majamaa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. rs762855 single nucleotide polymorphism modulates the risk for diffuse-type gastric cancer in females: a genome-wide association study in the Korean population.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
    Pooled it
  2. Distribution of theClinical medicine & research · 2020
    Pooled it
  3. Stable low prevalence of Huntington's disease in Finland.Clinical parkinsonism & related disorders · 2023
    Article
  4. Geographic differences in the incidence of Huntington's disease in Sardinia, Italy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Susanna YlönenDivision of Clinical Neuroscience (S.Y., K.M.), Neurology, University of Oulu; Department of Neurology and Medical Research Center (S.Y., K.M.), Oulu University Hospital; Department of Neurology (J.O.T.S.), North Karelia Central Hospital, Siun Sote, Joensuu; Division of Clinical Neurosciences (J.O.T.S.), Turku University Hospital; Neurology (J.O.T.S.), University of Turku; Department of Clinical Genetics (M.H.), Turku University Hospital; and Institute of Biomedicine (M.H.), University of Turku, Finland.
Jussi O T SipiläDivision of Clinical Neuroscience (S.Y., K.M.), Neurology, University of Oulu; Department of Neurology and Medical Research Center (S.Y., K.M.), Oulu University Hospital; Department of Neurology (J.O.T.S.), North Karelia Central Hospital, Siun Sote, Joensuu; Division of Clinical Neurosciences (J.O.T.S.), Turku University Hospital; Neurology (J.O.T.S.), University of Turku; Department of Clinical Genetics (M.H.), Turku University Hospital; and Institute of Biomedicine (M.H.), University of Turku, Finland.
Marja HietalaDivision of Clinical Neuroscience (S.Y., K.M.), Neurology, University of Oulu; Department of Neurology and Medical Research Center (S.Y., K.M.), Oulu University Hospital; Department of Neurology (J.O.T.S.), North Karelia Central Hospital, Siun Sote, Joensuu; Division of Clinical Neurosciences (J.O.T.S.), Turku University Hospital; Neurology (J.O.T.S.), University of Turku; Department of Clinical Genetics (M.H.), Turku University Hospital; and Institute of Biomedicine (M.H.), University of Turku, Finland.
Kari MajamaaDivision of Clinical Neuroscience (S.Y., K.M.), Neurology, University of Oulu; Department of Neurology and Medical Research Center (S.Y., K.M.), Oulu University Hospital; Department of Neurology (J.O.T.S.), North Karelia Central Hospital, Siun Sote, Joensuu; Division of Clinical Neurosciences (J.O.T.S.), Turku University Hospital; Neurology (J.O.T.S.), University of Turku; Department of Clinical Genetics (M.H.), Turku University Hospital; and Institute of Biomedicine (M.H.), University of Turku, Finland.
University of Oulu · FIOulu University Hospital · FITurku University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo study genetic causes of the low frequency of Huntington disease (HD) in the Finnish population, we determined

methodsA national cohort of patients with HD was used to identify families with mutant

resultsThe allele frequencies of

conclusionsThe low frequency of HD in Finland is partly explained by the low frequency of the HD-associated haplogroup A in the Finnish population. There were remarkable differences in intergenerational CAG repeat dynamics that depended on

Identifiers

PMID31086827
PMCPMC6481225
OpenAlexW2936871417

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.